User:Etienne Robillard/Notebook/Brainstorming

From OpenWetWare

Jump to: navigation, search

This page has moved here

Contents


Microglial activation in the PFC

  • Activation of the microglia by aluminium oxide disrupt the cytokine/neurotrophin balance.
  • Possible role of microglia-derived BDNF signaling on intracellular Ca2+ elevation? [1]

Nanotoxicity of fine particulate matter (PM2.5)

  • Fly-ash particulate matter includes:
    • aluminium oxide
    • silicon dioxide
    • titanium dioxide
    • barium oxide
    • iron oxide
    • cadmium
    • arsenic
    • dimethyl sulfate and monomethyl sulfate[2]
  • Exposure to coal fly ash is nanotoxic and may cause neuroinflammation via oxidative stress production. [3]
  • Coal fly ash is a source of particulate matter.
  • Fine particulate matter (PM2.5) exposure may induce chronic COPD pathogenesis.[4]

Neurodiversity

Neuropolitics

Phenomenology of consciousness

The brain is not the source of consciousness:

Intrinsic awareness (IA):

Ubiquity of consciousness:

Political manipulations of psychiatry

Sluggish schizophrenia

Retrograde signaling

Glycinergic neurotransmission trafficking

Allosteric modulation of glycine receptors by endocannabinoids

  • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [5]
  • Intracellular DHA delivery facilitate glutamatergic NMDA receptor function in the presence of glycine [6]
  • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

CB1-induced cholinergic neurotransmission

  • Hypothalamic POMC neurons promote CB1-induced feeding [7]
  • Adenosine antagonist (caffeine) potentiate corticostriatal neurotransmission (connectivity) through presynaptic CB1 receptor activation. [8]
  • Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [9]

Intracellular CB1/BDNF signaling

  • CB1 receptor activation may induce corticostriatal neuroprotection through a PI3K/Akt/mTORC1/BDNF pathway. [10]

Pineal gland

  • Dopamine receptors in the pineal gland may control melatonin production via anandamide trafficking? [11][12]

Social neuroscience of cannabis smoking

Synaptic hypercomputation

Biological utilization of quantum non-locality in microtubules:

Biophotonic non-locality of tubulin heterodimer:

  • The non-local (quantum) nature of biophotonic energy may require ultra-fast optical communication channels in MTs to potentiate a presynaptic action potential into a visible waveform! (Reference needed)
  • Is the tubulin dipole moment phase-dependent? (Reference needed)


Phase coherence of synaptic hypercomputation

Retrograde signaling and synaptogenesis:

References

  1. https://www.ncbi.nlm.nih.gov/pubmed/25171395 [Paper11]
    Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation.

  2. https://www.ncbi.nlm.nih.gov/pubmed/7350652

    [Paper8]

    Dimethyl and monomethyl sulfate: presence in coal fly ash and airborne particulate matter.

  3. http://particleandfibretoxicology.biomedcentral.com/articles/10.1186/1743-8977-2-10

    [Paper9]

    Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure.

  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617054/

    [Paper10]

    Fine particulate matter in acute exacerbation of COPD.

  5. https://www.ncbi.nlm.nih.gov/pubmed/16332990

    [Paper2]

    Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.

  6. https://www.ncbi.nlm.nih.gov/pubmed/7514666

    [Paper3]

    Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.

  7. https://www.ncbi.nlm.nih.gov/pubmed/25707796

    [Paper4]

    Hypothalamic POMC neurons promote cannabinoid-induced feeding.

  8. https://www.ncbi.nlm.nih.gov/pubmed/19027757

    [Paper5]

    Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.

  9. https://www.ncbi.nlm.nih.gov/pubmed/23858446

    [Paper6]

    Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.

  10. https://www.ncbi.nlm.nih.gov/pubmed/25698444

    [Paper7]

    The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

  11. https://www.ncbi.nlm.nih.gov/pubmed/18554250

    [Paper25]

    The rat pineal gland comprises an endocannabinoid system.

  12. https://www.ncbi.nlm.nih.gov/pubmed/26061461

    [Paper26]

    Rhythmic control of endocannabinoids in the rat pineal gland.

  13. https://www.jstage.jst.go.jp/article/jts/36/3/36_3_267/_article

    [Paper1]

    Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats

  14. http://pubs.rsc.org/en/content/articlelanding/2017/tx/c6tx00314a

    [Paper12]

    Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation.

  15. http://jaapl.org/content/35/4/469

    [Paper13]

    Amnesia and Crime.

  16. http://journal.frontiersin.org/article/10.3389/fphar.2016.00355/full

    [Paper14]

    Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function

  17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098150/

    [Paper15]

    Possible existence of optical communication channels in the brain

  18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653148/

    [Paper16]

    Endocannabinoid signaling mediates oxytocin-driven social reward

  19. https://www.ncbi.nlm.nih.gov/pubmed/11826965

    [Paper17]

    Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats.

  20. https://www.ncbi.nlm.nih.gov/pubmed/27264948

    [Paper18]

    Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review.

  21. https://www.ncbi.nlm.nih.gov/pubmed/26419755

    [Paper19]

    Vitamin D deficiency and essential hypertension.

  22. http://www.sciencedirect.com/science/article/pii/S2251729413000050

    [Paper20]

    Vitamin D as an effective treatment approach for drug abuse and addiction.

  23. https://www.ncbi.nlm.nih.gov/pubmed/24739187

    [Paper21]

    The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages.

  24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266250/

    [Paper22]

    Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance.

  25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783408/

    [Paper23]

    Psychosis and the Control of Lucid Dreaming.

  26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604174/

    [Paper24]

    Cannabis in the Treatment of Dystonia, Dyskinesias, and Tics.

  27. https://www.ncbi.nlm.nih.gov/pubmed/17439547

    [Paper27]

    Melatonin as a potential antihypertensive treatment.

  28. https://www.ncbi.nlm.nih.gov/pubmed/22527998

    [Paper28]

    Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects.

  29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955008/

    [Paper29]

    Multiple Mechanistically Distinct Modes of Endocannabinoid Mobilization at Central Amygdala Glutamatergic Synapses.

  30. https://www.ncbi.nlm.nih.gov/pubmed/28240187

    [Paper30]

    The endocannabinoid system modulating levels of consciousness, emotions and likely dream contents.

  31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489624/

    [Paper31]

    Insights into plant consciousness from neuroscience, physics and mathematics: A role for quasicrystals?

  32. https://www.researchgate.net/publication/285705600_Dreams_and_neuroholography_An_interdisciplinary_Interpretation_of_development_of_homeotherm_state_in_evolution

    [Paper31]

    Dreams and neuroholography: An interdisciplinary. Interpretation of development of homeotherm state in evolution

See also

Personal tools