- UT Southwestern, Neuroscience graduate program in the Laboratory of Dr. Jane Johnson
Neurogenesis and Gliogenesis of Ascl1 progenitor cells
Lineage tracing of Ascl1 (previously Mash1), a basic helix-loop-helix (bHLH) transcription factor involved in neuronal differentiation and specification during CNS development. Studying the novel and distinct functions of Ascl1 in neuronal versus oligodendrocyte progenitors during embryogenesis.
Battiste J, Helms AW, Kim EJ, Savage TK, Lagace DC, Mandyam CD, Eisch AJ, Miyoshi G, Johnson JE (2007) Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development 134:285-293.
Kim EJ, Leung CT, Reed RR, Johnson JE (2007) In vivo analysis of Ascl1 defined progenitors reveals distinct developmental dynamics during adult neurogenesis and gliogenesis. J Neurosci 27: 12764-12774.
Kim EJ, Battiste J, Nakagawa Y, Johnson JE (2008) Ascl1(Mash1) lineage cells contribute to discrete cell populations in CNS. Mol Cell Neurosci 38: 595-606.
Euiseok J. Kim
Department of Neuroscience
UT Southwestern Medical Center
5323 Harry Hines Blvd., NA 4-146
Dallas, TX 75390-9111