User:Federico Castro M/Undeveloped Ideas
These are ideas that are not completely developed; they might be very basic very crazy or form part of a project that is not currently developed. If you are interested in developing some of these ideas or are already working on them or something related, please contact me, I would be very glad to share information, collaborate and know about the outcome of the project.
- The problem with antibiotic resistance and VIH drug resistance is an evolutive problem. We could deal with that with an evolutionary approach; we should lead the bacteria or viruses to an isolated peak of adaptation and then submerge that peak.
- The immune system uses a library of sequences to assemble a great variety of proteins. We could construct and use a similar library of proteins for protein design (The Silver/Phillips method of assembly would be very useful for achieving this goal).
- Myxobacteria have the ability to generate complex structures. Could we isolate the genes responsible for that behavior and introduce it in Escherichia coli?
- A devise capable of certain function could be achieved, by randomly rewiring a genetic network with invertases and selecting the desired networks.
- Make a self destructive F plasmid, this would allow some information to be quickly delivered and once it is expressed it would disappear. The plasmid should codify for a restriction endonuclease that would digest the plasmid to tiny bits of DNA, the endonuclease should be very specific and have a very long recognition sequence to ensure that the Bacteria will not be harmed.
- We could use hormones as means of communication betwen bacteria, while there are some mechanisms implemented for communication, they lack the fast response that is often needed in a multicellular organism to coordinate cells (the molecule used by the luxR/l system as a signal, HSL, takes up to 24 hours to degradate). The system used for producing insulin and detecting the levels of sugars have already been developed by the NYMU 2007 iGEM team. It could be easily modified for communication between cells and the activity of the devise could be easily quantified with cheap medical equipments.
- Use DAP as means to produce a cell communication system, all the parts seemed to work (check the Paris iGEM team of 2007). that also would offer an alternative to the LuxR/LuxL.
- We could also measure POPs by other means than fluorescente shuch as the concentration of a diffusible insuline (insuline levels can be quantified very fast and fairly cheap) or antibiotic resistance (we could manually count the number of colonies). This could make the measurement available to laboratories with no funds or equipment and perhaps it would make it all easier.
- Also check My undeveloped projects