User:Jaroslaw Karcz/Modelling Sandbox

From OpenWetWare

Jump to: navigation, search



\nabla \times \nabla \times v = ...

\nabla \times v = \epsilon_{spq}v_{q,p}
\nabla \times \nabla \times v = \epsilon_{irs}(\epsilon_{spq}v_{q,p})_{,r}

\Rightarrow \epsilon_{irs} \epsilon_{spq} (v_{q,p})_{r}
\Rightarrow \epsilon_{sir}\epsilon_{spq}v_{q,pr}....cyclic permutation
\Rightarrow (\delta_{ip}\delta_{rq} -  \delta_{iq}\delta_{rp})v_{q,pr}
\Rightarrow \delta_{ip}\delta_{rq}v_{q,pr} -  \delta_{iq}\delta_{rp}v_{q,pr}
\Rightarrow \delta_{ip}v_{r,pr} -  \delta_{iq}v_{q,rr}
\Rightarrow v_{r,ir} - v_{i,rr}
\Rightarrow v_{r,ri} - v_{i,rr} ......since.....  v_{r,ri} =  v_{r,ir} ...continuous function

Convert to vector notation

\Rightarrow\nabla (\nabla \cdot  v) - \nabla^{2}v

Model Development

The process of modelling consists of a number of layers; the following is a description of the modelling workflow:

  1. Definition of the problem
  2. Verification of information available
  3. Selection of model structure
  4. Establishing a simple model
  5. Sensitivity analysis
  6. Experimental tests of the model predictions
  7. Stating the agreements and divergences between experimental and modelling results, including any emergent behaviour
  8. Iterative refinement of model

f_{obj}(k) = \sum_{i=1}^q (f_{obs}(i) - f_{per}(i,k))^2

Back to Home Infector Detector Jump to Dry Lab

Home Dry Lab Modelling

Part Main Page        Transfer Function        Specificity        Response time        Stability        Add Data       


The real world is dominated by complexity, especially biological systems
Mathematical modelling and computer simulations provide a means of understanding the innate funtioning of system - dynamics, and to arrive at well-founded predictions about their future development and the effect of interactions with the environment. So what is a model? A model is an abstract representation of objects and processes that explain the features/nature of these objects or processes. We present the model of our construct, as a system of differential equations to describe the dynamics of that network.

Model Parameters

Parameter Value Description Comment (literature, derived?)
k1 x [units] max. transcription rate of constitutive promoter (pTET) Estimate
k6 x [units]
δGFP 0.029 hrs -1 degradation rate of GFP Literature ~~ give reference


Personal tools