User:Lindenb/Notebook/UMR915/20100906
Test for a Local Gene Wiki
Created a Box as a mediawiki template. Just add {{NcbiGeneACCN1}} in the wiki text.
- NCBI GeneID
- 40
- Official Symbol
- ACCN1
- Full Name
- amiloride-sensitive cation channel 1, neuronal
- Location
- 17q12
- See related
- HGNC:99 Ensembl:ENSG00000108684 HPRD:03471 MIM:601784
- Other Names
- ACCN; BNC1; MDEG; ASIC2; BNaC1; ASIC2a; hBNaC1;
- Organism
- Homo sapiens
- Lineage
- Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
ACCN1
"This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified"
