User:Nancy Ouyang/Notebook/20.020(S10)/2010/03/17

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System-Level Design 2020(S10)_Lecture:week_7#Week_7_Studio Breaking down a complicated problem into simpler parts: System > Device > Part > DNA Nutrient recycling Main nutrients: P, N, K, Ca, Mg, S Focus on metabolic engineering for just two Codependence Should not be too difficult, known art. endocrine signals. Biomolecules as signals which diffuse, NOT proteins (which only work if cells right next to each other) b/c bacteria and algae are fairly far apart in tank Term is (not sure) commensalism? Decontamination Against mold, insects, etc. Goals: inexpensive, not environmentally harmful, not easy to evolve resistance to Engineer bac and alg to tolerate cold? But probably decreased efficiency Look at extremophiles Worries Algae output locked up in algae? Bacteria growing out of control and crashing? System Diagram image: Components that need biological engineering: Oil secretion Nutrient recycling Steady state (constitutively attempt recycle nutrients) or what? If constitutively, will always have enough nutrients, but energy costs and possibly bacteria population crash Worry about start state Especially if know that going to be rebooting frequently, start state becomes important Notes Investigate prior arr: Commensalism, there's previous research. Yeast and tryptophan, also something about mammalian cells Growth temperature syncing Worry about Mutations in our algae / bacteria Biology: not absolute, probabilities Perhaps have an expected "shelf life" Have the bacteria produce antibodies, and only system reboot when superbug comes along