User:Ran Taube

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Current Address

Ran Taube

• Department of Virology and Developmental Genetics,
• The National Institute of Biotechnology in the Negev, Ben-Gurion University, ISRAEL
• email address:rantaube@bgu.ac.il
• Tel; 08-6479945

2005-2007 Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute Harvard Medical School, Boston

2001-2004 Senior Scientist- QBI, Israel Manager of the BL-3 facility

1998-2001 Post doctoral fellow, Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, CA. USA

1992-1997 Ph.D. with honors, Tel Aviv University, Sackler Medical School, Dep. of Cell Biology and Histology

Biochemical studies on the reverse transcriptase of mouse mammary tumor virus and human immunodeficiency virus type 2

1990-1992 M.Sc. Tel Aviv University, Department of Microbiology and Biotechnology.

Title of thesis: Isolation and characterization of bacteria using fertilizer and emulsification for Growth”

1986-1989 B.Sc. Tel Aviv University, Life Sciences Faculty

Publications

• Taube, R., Zhu Q.K., Diaz-Griffero, F., Dwyer, M. and Marasco., W.A (2008) Lentivirus Display: Stable Expression of Human Antibodies on the Surface of Viral Particles and Human Cells. in prep.
• Felipe Diaz-Griffero, Ran Taube, Stefan Muelbauer and Jurgen Brojasch (2008) Efficient maturation of HIV Gag and production of HIV-like particels in murine cells. accepted BBRC.
• Fujinaga, K., Irwin, D., Huang, Y., Taube, R., Kuroosu, T. and Peterlin, B.M. (2004) Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element. Mol. Cell. Biol. 24(2):787-95.
• Fujinaga, K, Irwin D, Taube R, Zhang F, Geyer M, Peterlin BM (2002). A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells. J Virol. ;76(24):12934-9.
• Lin, X , Taube, R., Fujinaga, K., and Peterlin, B.M. (2002) P-TEFb containing cyclin K and CDK9 can activate transcription via RNA. J Biol Chem. 10;277(19):16873-8..
• Taube, R., Lin, X., Irwin, D., Fujinaga, K., and Peterlin, B.M. (2002) Interaction between P-TEFb and the C-Terminal Domain of RNA Polymerase II Activates Transcriptional Elongation from Site Upstream or Downstream of Target Genes. Mol. Cell. Biol. 22: 321-331.
• Barboric, M., Taube, R., Nekrep, N., Fujinaga, K. and Peterlin, B.M. (2000) The binding of Tat to TAR and the recruitment of P-TEFb occur independently in BIV. J Virol. 74(13):6039-44.
• first bullet Sawaya BE, Khalili K, Gordon J, Taube R, Amini S. (2000) Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome. J. Biol. Chem. 10;27 (45) 35209-14.
• Chao SH, Fujinaga K, Marion JE, Taube R, Sausville EA, Senderowicz AM, Peterlin BM, Price DH. (2000) Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J.Biol.Chem 15:275 (37) 28345-8.
• Taube, R., Fujinaga, K., Wimmer, J., Baboric, M. and Peterlin, B.M. (1999): Tat Transactivation: A Model for the Regulation of Eukaryotic Transcriptional Elongation. Virology, 264, 245-253.
• Taube, R., Fujinaga, K., Irwin, D., Wimmer, J., Geyer, M. and Peterlin, B.M. (2000): Interactions Between Equine Cyclin T, Tat and TAR are Disrupted by a Leucine to Valine Substitution Found in Human Cyclin T. J.Virol., 74 (2):892-898.
• Wimmer, J., Fujinaga, K., Taube, R., Cujec, T., Zhu, Y., Peng, J., Price, D.H. and Peterlin, B.M. (1999): Interactions between Tat and TAR and Human Immunodeficiency Virus Replication are Facilitated by Human Cyclin T1 but not Cyclins T2a or T2b. Virology, 255 ,182-189.
• Fujinaga, K., Taube, R., Wimmer, J. (equal contribution), Cujec, T. and Peterlin, B.M. (1999): Interactions between Human Cyclin T, Tat and TAR are Disrupted by a Sistine to Tyrosine Substitution Found in Mouse Cyclin T. Proc. Natl. Acad. Sci. U.S.A. 96,1285-1290.
• Taube, R., Avidan, O., Bakhanashvili, M. and Hizi, A. (1998): DNA Synthesis Exhibited by the Reverse Transcriptase of Mouse Mammary Tumor Virus: Processivity and Fidelity of Misinsertion and Mispair Extension. Eur. J. Biochem. 258, 1032-1039.
• Taube, R., Loya, S., Avidan, O., Perach, M. and Hizi, A. (1998): Reverse Transcriptase of Mouse Mammary Tumor Virus: Expression in Bacteria, Purification and Biochemical Characterization. Biochem. J. 329, 579-587.
• Taube, R., Avidan, O. and Hizi, A. (1997): The Fidelity of Misinsertion and Mispair Extension Throughout DNA Synthesis Exhibited by the Reverse Transcriptase of Human Immunodeficiency Virus Type 2 Resistant To Nucleoside Analogs. Eur. J. Biochem. 250,106-114.
• Rubinek, T., Bakhanashvili, M., Taube, R., Avidan, O. and Hizi, A. (1997): The Fidelity Of 3’ Misinsertion and Mispair Extension During DNA Synthesis Exhibited by Two Drug-Resistant Mutants of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 Leu74 Val And Glu89Gly. Eur. J. Biochem. 247,238-247.