User:Scott P. Tarone

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Scott P. Tarone (an artistic interpretation)
Scott P. Tarone (an artistic interpretation)

I am an independent researcher, self-taught in the biosciences with a focus on Immunology and Targeted Cancer Therapies. I proposed a targeted cancer therapeutic in a paper that was published in Drug Discovery Today.(http://www.sciencedirect.com/science/article/pii/S1359644615000653).

Currently I am teaching myself computational chemistry; specifically protein and small molecule therapeutic design.

Education

  • Year, PhD, Institute
  • Year, MS, Institute
  • Year, BS, Institute

Research interests

  1. Interest 1
  2. Interest 2
  3. Interest 3

Publications

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  1. Error fetching PMID 25668580: [Paper1]

Intracellular Caspase-Modulating Chimeric Antigen Receptor

  • Intracellular agent targets mutant proteins and induces apoptosis.
  • Chimera with a targeting domain, a molecular switch and a pro-apoptotic effector.
  • A constitutively active caspase-3 mutant (V266E), efficient at low concentrations.
  • Engineered mAb or zinc finger targeting tumor-specific mutations.
  • Inteins provide flexible platform for control of protein function.

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