User:Steven J. Koch/MTC/March 29 2011
- Review last HW
- Summary of Kramers' reaction rate theory (we'll discuss in detail following lectures, diffusion, etc.)
- Group work: Given prefactor of 10^-9 per second, Calculate bond lifetimes for energy barriers of: 1, 10, 20, and 40 kT
- Bond lifetime under force
- Why do we care?
- Evan Evans: Everything about cells is kinetics, not equilibrium diffEQ
- Famous example: luekocyte rolling]
- RNA Polymerase II / nucleosome barriers
- Kinesin neck linker (see Larry's paper)
- Set-up the problem
- Group work: intuition
- Solve expected PDF for bond "strength" assuming constant force ramp rate, other assumptions
- Preview next HW
- Articles added to Mendeley
- Easiest to follow: Evan Evans' Annual Review (2001): Evans, E. (2001). Probing the relation between force--lifetime--and chemistry in single molecular bonds. Annual review of biophysics and biomolecular structure, 30, 105-28. doi: 10.1146/annurev.biophys.30.1.105.
- Thorough: Hänggi, P., Talkner, P., & Borkovec, M. (1990). Reaction-rate theory: fifty years after Kramers. Reviews of Modern Physics, 62(2), 251-341. doi: 10.1103/RevModPhys.62.251.
- Bell, G. (1978). Models for the specific adhesion of cells to cells. Science, 200(4342), 618-627. doi: 10.1126/science.347575.
- Wikipedia article on George Bell
- Wikipedia article on Kramers (needs improvement!)
Whiteboard photos from today