User:Ting Wang

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Contact Info

Image:Ting_Wang_PhD_copy.jpg‎

Ting Wang, PhD
The University of Arizona
1656 E Mabel Street
Medical Research Building, Room 411
P.O. Box 245218
Phone: (520) 626-4472
Fax: (520) 626-2757
Email: twang@email.arizona.edu

Education

  • 2005, PhD (Pharmaceutical Sciences), the University of South Carolina
  • 2001, BS (Biochemistry), Nanjing University, China


Positions and Employment

  • 2013-present
    Assistant Professor of Medicine (Tenure Eligible)
    Division of Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine, the University of Arizona

  • 2010-2013
    Research Assistant Professor
    Section of Pulmonary and Critical Care, Department of Medicine, University of Illinois at Chicago, Chicago, IL

  • 2006-2010
    Postdoctoral Fellow (Supervisor: Joe GN Garcia, MD)
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, IL

  • 2005-2006
    Postdoctoral Fellow (Supervisor: Hua Linda Cai, MD, PhD)
    Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL

  • 2001-2005
    Research Assistant
    College of Pharmacy, University of South Carolina, Columbia, SC


Research interests

  1. Cardiopulmonary toxicity of particulate matter air pollution
  2. Lung biology of acute lung injury and asthma
  3. Lung genomics and genetics


Awards

  • Jinshiyuan Scholarship (1998) Nanjing University, China
  • Graduate Student of the Year Award (2005) University of South Carolina
  • Graduate Teaching Assistant Award (2005) University of South Carolina
  • Travel Award (2008) Central Society for Clinical Research
  • DOM Research Day Award (2008) Department of Medicine, University of Chicago
  • Travel Award (2009) Central Society for Clinical Research
  • Travel Award (2011) Central Society for Clinical Research
  • Parker B Frances Fellowship (2012) PBF Family Foundation
  • Best Abstract Award (2012) University of Illinois Hospital and Health Science System
  • Travel Award (2013) Central Society for Clinical and Translational Research
  • AFMR Scholar Award (2013) American Federation for Medical Research
  • K-Award (2014) Central Society for Clinical and Translational Research


Publications

In press

  1. Zhou T, Wang T*, Garcia JG*. A Non-Muscle Myosin Light Chain Kinase-Dependent Gene Signature In Blood PBMCs Is Linked To Human Asthma Severity And Exacerbation Status. Pulm Circ. 2014 Accepted for publication. (*, co-corresponding author)
  2. Wang T, Zhou T*, Saadat L, Garcia JG. A MYLK Variant Regulates Asthmatic Inflammation via Alterations in mRNA Secondary Structure. Eur J Hum Genet. 2014 Oct 1. [Epub ahead of print]. PMID: 25271083 (*, co-first author)


2014 (University of Arizona)

  1. Sun X, Ramamoorthi Elangovan V, Mapes B, Camp SM, Sammani S, Saadat L, Ceco E, Ma SF, Flores C, MacDougall MS, Quijada H, Liu B, Evenoski CL, Wang T, Chiang ET, Garcia JG. The NAMPT Promoter is Regulated by Mechanical Stress, STAT5, and ARDS-Associated Genetic Variants. Am J Respir Cell Mol Biol. 2014 Nov;51(5):660-7.
  2. Gu W, Xu Y, Xie X, Wang T, Ko JH, Zhou T. The role of RNA structure at 5’-Untranslated Region in microRNA-mediated gene regulation. RNA. 2014 Sep;20(9):1369-75.
  3. Zhou T, Wang T*, Garcia JG. Expression of nicotinamide phosphoribosyltransferase-influenced genes predicts recurrence-free survival in lung and breast cancers. Sci Rep. 2014 Aug 22;4:6107. (*, co-first author)
  4. Zhou T and Wang T. A novel approach to investigate functional exonic SNPs associated with lung diseases at post-transcriptional stage. Int J Pulm Respir Med. 2014 Aug;1:002e.
  5. Moreno-Vinasco L, Quijada H, Sammani S, Siegler J, Letsiou E, Deaton R, Saadat L, Zaidi RS, Messana J, Gann PH, Machado RF, Ma W, Camp SM, Wang T, Garcia JG. Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury. Am J Respir Cell Mol Biol. 2014 Aug;51(2):223-8.
  6. Wang T, Moreno-Vinasco L, Ma SF, Zhou T, Shimizu Y, Sammani S, Epshtein Y, Watterson DM, Dudek SM, Garcia JG. Nonmuscle Myosin Light Chain Kinase Regulates Murine Asthmatic Inflammation. Am J Respir Cell Mol Biol. 2014 Jun;50(6):1129-35.
  7. Goldman JL, Sammani S, Kempf C, Saadat L, Letsiou E, Wang T, Moreno-vinasco L, Rizzo AN, Fortman JD, Garcia JG. Pleiotropic effects of interleukin 6 in a “two hit” murine model of acute respiratory distress syndrome. Pulm Circ. 2014 Jun;4(2):280-8.
  8. Gu W, Li M, Xu Y, Wang T, Ko JH, Zhou T. Increased conservation level at mRNA structurally sensitive sites from bacteria to mammal. BMC Evol Biol. 2014 Apr 23;14(1):87.
  9. Zhou T, Wang T*, Garcia JG. Non-muscle myosin light chain kinase mediated genes: insight into prognosis in human cancers. PLoS One. 2014 Apr 8;9(4):e94325. (*, co-first author)
  10. Wang L, Sammani S, Moreno-Vinasco L, Letsiou E, Wang T, Camp SM, Bittman R, Garcia JG, Dudek SM. FTY720 (S)-Phosphonate Preserves Sphingosine 1-Phosphate Receptor 1 Expression and Exhibits Superior Barrier Protection to FTY720 in Acute Lung Injury. Crit Care Med. 2014 Mar;42(3):e189-99.


Before 2014

  1. Wang T*, Garcia JG, Zhang W. Epigenetic Regulation in Particulate Matter-Mediated Cardiopulmonary Toxicities: A Systems Biology Perspective. Curr Pharmacogenomics Person Med. 2012 Dec;10(4):314-321. (*, co-corresponding author)
  2. Wang T, Wang L, Zaidi SR, Sammani S, Siegler J, Moreno-Vinasco L, Mathew B, Natarajan V, Garcia JG. Hydrogen Sulfide Attenuates Particulate Matter-Induced Human Lung Endothelial Barrier Disruption via Combined ROS Scavenging and Akt Activation. Am J Respir Cell Mol Biol. 2012 Oct;47(4):491-6.
  3. Wang T, Wang L, Moreno-Vinasco L, Lang GD, Sullivan R, Usatyuk PV, Samet JM, Breysse PN, Geyh AS, Natarajan V, Garcia JG. Disruption of Endothelial Cell Barrier Integrity by Particulate Matter Air Pollution via Calpain-Mediated Tight Junction Protein Degradation. Part Fibre Toxicol. 2012 Aug 29;9(1):35.
  4. Shen K, Wang T, Garcia JGN. MYLK (myosin light chain kinase). Atlas Genet Cytogenet Oncol Haematol. 2012; 16(12):901-908.
  5. Wang T, Lang GD, Moreno-Vinasco L, Huang Y, Goonewardena SN, Peng YJ, Svensson EC, Natarajan V, Lang RM, Linares JD, Breysse PN, Geyh AS, Samet JM, Lussier YA, Dudley S, Prabhakar NR, Garcia JG. Particulate Matter Induces Cardiac Arrhythmias via Dysregulation of Carotid Body Sensitivity and Cardiac Sodium Channels. Am J Respir Cell Mol Biol. 2012 Apr;46(4):524-31.
  6. Ma SF, Xie L, Pino-Yanes M, Sammani S, Wade MS, Letsiou E, Siegler J, Wang T, Infusino G, Kittles RA, Flores C, Zhou T, Prabhakar BS, Moreno-Vinasco L, Villar J, Jacobson JR, Dudek SM, Garcia JG. Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury. Am J Respir Cell Mol Biol. 2011 Dec;45(6):1203-11.
  7. Sammani S, Park KS, Zaidi SR, Mathew B, Wang T, Huang Y, Zhou T, Lussier YA, Husain AN, Moreno-Vinasco L, Vigneswaran WT, Garcia JG. A Sphingosine 1-Phosphate 1 Receptor Agonist Modulates Brain Death-Induced Neurogenic Pulmonary Injury. Am J Respir Cell Mol Biol. 2011 Nov;45(5):1022-7.
  8. Mitra S, Sammani S, Wang T, Boone DL, Meyer NJ, Dudek SM, Moreno-Vinasco L, Garcia JG, Jacobson JR. Role of GADD45a in Akt Phosphorylation and Ubiquitination Following Mechanical Stress-Induced Vascular Injury. Am J Respir Crit Care Med. 2011 Nov 1;184(9):1030-40.
  9. Mathew B, Jacobson JR, Berdyshev E, Huang Y, Sun X, Zhao Y, Gerhold LM, Siegler J, Evenoski C, Wang T, Zhou T, Zaidi R, Moreno-Vinasco L, Bittman R, Chen CT, Lariviere PJ, Sammani S, Lussier YA, Dudek SM, Natarajan V, Weichselbaum RR, Garcia JG. Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J. 2011 Oct;25(10):3388-400.
  10. Mathew B, Huang Y, Jacobson JR, Berdyshev E, Wang T, Moreno-Vinasco L, Lang G, Zhao Y, Gerhold L, Bittman R, Chen CT, LaRiviere PJ, Mauceri H, Sammani S, Dudek SM, Natarajan V, Lussier YA, Weichselbaum RR, Garcia JGN. Sphingolipids mediate radiation lung injury: Attenuation by statins and sphingosine 1-phosphate. Am J Respir Cell Mol Biol. 2011 Mar;44(3):415-22.
  11. Mirzapoiazova T, Sammani S, Moitra J, Moreno-Vinasco L, Chiang ET, Wang T, Camp SM, Dudek SM, Turner J, Garcia JGN. The Non Muscle Myosin Light Chain Kinase Isoform is a Viable Molecular Target in Acute Inflammatory Lung Injury. Am J Respir Cell Mol Biol. 2011 Jan;44(1):40-52.
  12. Youn JY, Wang T, Blair J, Laude KM, Oak JH, McCann LA, Harrison DG, and Cai H. Endothelium-specific Sepiapterin Reductase Deficiency in DOCA-salt Hypertension. Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2243-9.
  13. Sammani S, Moreno-Vinasco L, Mirzapoiazova T, Singleton PA, Chiang ET, Evenosky C, Wang T, Mathew B, Husain A, Moitra J, Sun X, Nunez L Jacobson J, Dudek SM, Natarajan V, Garcia JGN. Differential Effects of S1P Receptors on Airway and Vascular Barrier Function in the Murine Lung. Am J Respir Cell Mol Biol. 2010 Oct;43(4):394-402.
  14. Wang T, Chiang ET, Moreno-Vinasco L, Pendyala S, Samet JM, Geyh AS, Breysse PN, Lussier YA, Natarajan V, Garcia JG. Particulate Matter Disrupts Endothelial Integrity via an ROS-p38 MAPK Dependent Pathway. Am J Respir Cell Mol Biol. 2010 Apr;42(4):442-9.
  15. Youn JY, Wang T, Cai H. An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production. Circ Res. 2009;104(1):50-9.
  16. Gao L, Pung YF, Zhang J, Chen P, Wang T, Li M, Meza M, Toro L, Cai H. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H331-9
  17. Zhao Y, Usatyuk PV, Gorshkova IA, He D, Wang T Moreno-Vinasco L, Geyh AS, Breysse PN, Samet JM, Spannhake EW, Garcia JG, Natarajan V. Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. Am J Respir Cell Mol Biol. 2009;40(1):19-30.
  18. Chiang ET, Wang T, Garcia JG. Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection and Vascular Biomarkers. Textbook of Pulmonary Vascular Disease (Editor: Yuan XJ et.al.) 2009 Springer.
  19. Wang T, Moreno-Vinasco L, Huang Y, Lang GD, Linares JD, Goonewardena SN, Grabavoy A, Samet JM, Geyh AS, Breysse PN, Lussier YA, Natarajan V, Garcia JG. Murine Lung Responses to Ambient Par-ticulate Matter: Genomic Analysis and Contribution to Airway Hyperresponsiveness. Environ Health Perspec. 2008; 116(11):1500-8
  20. Xia B, Wang T, Fox LM, Wang D. HPLC/MS/MS analysis of 3-carbamyl-4-methylpyrrole analog MNP001, a highly potent antihypertensive agent, in rat plasma. J Chromatogr B. 2009;877(20):1867-72.
  21. Wang T, Wang D. High performance liquid chromatographic analysis of MS23 piperidine analog MSP001 in rat plasma. J Pharm Biomed Anal. 2006;42(5):607-12
  22. Wang T, Fox LM, Wang D. Validation of HPLC Analysis Method of a Novel Antihypertensive Agent MS23 in Rat Plasma. J Chromatogr B. 2006;830(1):13-7
  23. Wang D, Wang T. Novel approaches to using PDE4 inhibitors for antihypertensive therapy. Curr Opin Investig Drugs. 2005;6 (3) 283-8


Useful links

  • [1] Google Scholar Citation
  • [2] University of Arizona Webpage
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