IGEM:Harvard/2006/DNA nanostructures: Difference between revisions

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==Bibliography==
<div class="tabs-blue">
<ul>
<li id="current">[[IGEM:Harvard/2006/DNA nanostructures|Project Overview]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Designs|Designs]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Notebook|Notebook]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Protocols|Protocols]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Presentations|Presentations]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Literature|Literature]]</li>
</ul>
</div>
<br style="clear:both">


===Thrombin===
<biblio>
# thr1 pmid=15170395
# thr2 pmid=6996572 
</biblio>
<br>


===Thrombin-Aptamer===
==Project Overview==
<biblio>
*Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
# tha1 pmid=15945116
*The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
</biblio>
*As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
<br>
*We expect that molecular containers could have several interesting scientific and clinical applications, such as
**Drug and gene delivery
**Bio-marker scavenging (early detection of biomarkers)
**Directed evolution (compartmentalized selections)
**Using multiplexing for combinatorial chemical synthesis
**Capture and stabilization of multiprotein complexes
**Protein folding (chaperones)
**Cell sorting


===DNA Bioavailability===
==Working Team Members==
<biblio>
*[[User:TChan|Tiffany Chan]] ([[User_talk:TChan|talk]], [[Special:Contributions/TChan|edits]])
# bioa1 pmid=16146351
*[[User:Kfifer|Katherine Fifer]] ([[User_talk:Kfifer|talk]], [[Special:Contributions/Kfifer|edits]])
# bioa2 pmid=11336355
*[[User:Vlau|Valerie Lau]] ([[User_talk:Vlau|talk]], [[Special:Contributions/Vlau|edits]])
# bioa3 pmid=7667185
*[[User:Matthewmeisel|Matthew Meisel]] ([[User_talk:Matthewmeisel|talk]], [[Special:Contributions/Matthewmeisel|edits]])
</biblio>
*[[User:Lhahn|Lewis Hahn]] ([[User_talk:Lhahn|talk]], [[Special:Contributions/Lhahn|edits]])
<br>
*TA: [[User:ShawnDouglas|Shawn Douglas]] ([[User_talk:ShawnDouglas|talk]], [[Special:Contributions/ShawnDouglas|edits]])


===Size of Box===
==Recent Changes==
 
{{Special:Recentchanges/b=IGEM:Harvard/2006/DNA_nanostructures/&limit=20}}
===Covering With PEG?===

Latest revision as of 01:15, 29 October 2006



Project Overview

  • Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
  • The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
  • As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
  • We expect that molecular containers could have several interesting scientific and clinical applications, such as
    • Drug and gene delivery
    • Bio-marker scavenging (early detection of biomarkers)
    • Directed evolution (compartmentalized selections)
    • Using multiplexing for combinatorial chemical synthesis
    • Capture and stabilization of multiprotein complexes
    • Protein folding (chaperones)
    • Cell sorting

Working Team Members

Recent Changes

List of abbreviations:
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