IGEM:Harvard/2006/DNA nanostructures: Difference between revisions

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<ul>
<li id="current">[[IGEM:Harvard/2006/DNA nanostructures|Project Overview]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Designs|Designs]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Notebook|Notebook]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Protocols|Protocols]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Presentations|Presentations]]</li>
<li>[[IGEM:Harvard/2006/DNA_nanostructures/Literature|Literature]]</li>
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==Project Overview==
==Project Overview==
*Our goal is to to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
*Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
*The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
*The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
*As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
*As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
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**Cell sorting
**Cell sorting


==Container Designs==
==Working Team Members==
<gallery>
*[[User:TChan|Tiffany Chan]] ([[User_talk:TChan|talk]], [[Special:Contributions/TChan|edits]])
Image:Igemharv06_Katie_Val_cylinderI.gif|[[IGEM:Harvard/2006/Container Design 1|Design 1]]<br>hexagonal core, separate 1-ply lids
*[[User:Kfifer|Katherine Fifer]] ([[User_talk:Kfifer|talk]], [[Special:Contributions/Kfifer|edits]])
Image:Smallcontainerdesign2.jpg|[[IGEM:Harvard/2006/Container Design 2|Design 2]]<br>hexagonal core, separate 2-ply lids
*[[User:Vlau|Valerie Lau]] ([[User_talk:Vlau|talk]], [[Special:Contributions/Vlau|edits]])
Image:Igemharv06_msmrect.png|[[IGEM:Harvard/2006/Container Design 3|Design 3]]<br>rectangular core, continuous 1-ply lids
*[[User:Matthewmeisel|Matthew Meisel]] ([[User_talk:Matthewmeisel|talk]], [[Special:Contributions/Matthewmeisel|edits]])
</gallery>
*[[User:Lhahn|Lewis Hahn]] ([[User_talk:Lhahn|talk]], [[Special:Contributions/Lhahn|edits]])
 
*TA: [[User:ShawnDouglas|Shawn Douglas]] ([[User_talk:ShawnDouglas|talk]], [[Special:Contributions/ShawnDouglas|edits]])
 
==Coding==
===Existing code===
*[[IGEM:Harvard/2006/DNA_nanostructures/Designing_DNA_nanostructures|William's code (Python)]]
 
==Presentations==
 
===Most recent (Week 3)===
* [[IGEMHarv06 Week3 presentation VKTM.ppt|Week 3 Presentation: Design Progress]]


===Week 2: Original proposal===
==Recent Changes==
* [[IGEM:Harvard/2006/DNA_nanostructures/Presentation_proposal|Presentation Proposal]]
{{Special:Recentchanges/b=IGEM:Harvard/2006/DNA_nanostructures/&limit=20}}

Latest revision as of 01:15, 29 October 2006



Project Overview

  • Our goal is to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
  • The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
  • As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
  • We expect that molecular containers could have several interesting scientific and clinical applications, such as
    • Drug and gene delivery
    • Bio-marker scavenging (early detection of biomarkers)
    • Directed evolution (compartmentalized selections)
    • Using multiplexing for combinatorial chemical synthesis
    • Capture and stabilization of multiprotein complexes
    • Protein folding (chaperones)
    • Cell sorting

Working Team Members

Recent Changes

List of abbreviations:
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