Small molecule binding by SPR: Difference between revisions
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Drug-like small organic molecules often do not dissolve well in water. To profile binding of small molecules with SPR, small concentration (<10%) of DMSO is used to improve drug solubility. | |||
A common technique is to add DMSO solution of drug to the aqueous buffer <cite>karlsson1</cite>. | |||
Dielectric properties of DMSO and water are significantly different and significant mismatch of {{SPR:RU}} | |||
<biblio> | |||
#karlsson1 pmid=10821711 | |||
<biblio> | |||
[[Category:SPR]] | [[Category:SPR]] | ||
Revision as of 22:51, 7 April 2008
Drug-like small organic molecules often do not dissolve well in water. To profile binding of small molecules with SPR, small concentration (<10%) of DMSO is used to improve drug solubility. A common technique is to add DMSO solution of drug to the aqueous buffer [1].
Dielectric properties of DMSO and water are significantly different and significant mismatch of RU
<biblio>
- karlsson1 pmid=10821711
<biblio>
