BMCB625:Mathematics in Biology

Papers

Outline of Talk and Discussion

1. Introduction and background
2. "Classic Paper" (as reference) and "Cutting Edge Paper" (main emphasis) and how they relate to one another
3. Summary and key points to begin discussion
4. OPEN discussion (intended to be an informal discussion on the interface between Mathematics and biology (specifically biochemistry)).

PAPERS:

• MAIN PAPER: "Multistability in the lactose utilization network of Escherichia coli"

EM Ozbudak, et al, Nature 427, 737-740 (19 February 2004) [[1]]

• CLASSIC: "Mutations of Bacteria from Virus Sensitivity to Virus Resistance"

S. E. Luria and M. Delbrück, Genetics. 1943 November; 28(6): 491–511 [[2]]

Chris - Bonus Materials

A good primer on how biologists and engineers look at a problem in different ways; while many comments do not address the complexity of biochemistry and genetics, it does provide an interesting perspective on what we consider "important." Also, of importance, in my opinion, is developing a common language by which numerous disciplines can communicate. I'll touch more on this particular topic during my talk. Y. Lazebnik, "Can a Biologist Fix a Radio? or, What I Learned while Studying Apoptosis" [[3]]

(Homework) Questions

Larry

Chayne

Mahta

Jon

Chris

Jeremy