BMCB625:Schedule
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Contents |
General Info
- Spring 2007
- Location: BRB 603. Wednesdays from 9:30 - 11:30 (practice and review session) and Thursdays (The Real Thang) from 10:30 - 12:30
- How the Class Works
Week-by-Week Schedule Summary
| Date | Presenters | Topic | Evaluator/MC/Faculty |
| April 4 | Hoatlin/Dresbeck | Org Meeting | NA |
| April 12 | Chris & Maureen | BMCB625:DNA Replication | JF/CP/(Hoatlin&Thayer) |
| April 19 | Chayne & Larry | BMCB625:DNA Replication (New components) | JL/CS (Hoatlin/Thayer) |
| April 26 | Jeremy & Chayne | BMCB625: noncoding RNA (Xist) | LG/JF (Thayer) |
| May 2 (Wed) | BMCB625: Bringing it all together - DNA replication and NC RNA | ||
| May 17 | Jon (Happy Birthday) & Jeremy | BMCB625:Nucleosome Coding | CS/MN(Lundblad?) |
| May 24 | Larry & Jon | BMCB625:Helicases | MN/JL (Hoatlin/Chapman) |
| May 31 | Mahta & Chris | BMCB625:Exon Jxn Complex | CP/LG(Rotwein/Landfear?) |
| June 7 | Chris | BMCB625:Mathematics in Biology | (Chayne, MC) (Shinde?, Farrens?) |
| June 7 | Chayne | BMCB625:DNA Gyrase | (Chris, MC) (Hoatlin/Thayer/Smolik) |
| June 13 | Mahta | BMCB625:Noncoding Y RNA | (Jeremy, MC) (Thayer/Rotwein?) |
| June 13 | Jeremy | BMCB625:ncRNA | (Mahta, MC) (Thayer) |
| June 14 | Larry | BMCB625:pol-Y (Excision Repair) | (Jon, MC) (Hoatlin/Lloyd/McCullough) |
| June 14 | Jon | BMCB625:Topo | (Larry, MC) |
Proposed Papers
Method
- Enlist a faculty mentor
- send them the paper
- make sure the date works
- vote by wiki?
- Make sure there is consensus (excitement) among remaining class members about the proposed paper
- again, vote can be done on wiki
Suggestions
Proposed Paper for Discussion--Contact Chayne for inquiries
- Nöllmann M, Stone MD, Bryant Z, Gore J, Crisona NJ, Hong SC, Mitelheiser S, Maxwell A, Bustamante C, and Cozzarelli NR. . pmid:17334374.
Abstract:
E. coli DNA gyrase uses the energy of ATP hydrolysis to introduce essential negative supercoils into the genome, thereby working against the mechanical stresses that accumulate in supercoiled DNA. Using a magnetic-tweezers assay, we demonstrate that small changes in force and torque can switch gyrase among three distinct modes of activity. Under low mechanical stress, gyrase introduces negative supercoils by a mechanism that depends on DNA wrapping. Elevated tension or positive torque suppresses DNA wrapping, revealing a second mode of activity that resembles the activity of topoisomerase IV. This 'distal T-segment capture' mode results in active relaxation of left-handed braids and positive supercoils. A third mode is responsible for the ATP-independent relaxation of negative supercoils. We present a branched kinetic model that quantitatively accounts for all of our single-molecule results and agrees with existing biochemical data.
Stats
- make sure each of you has a slot as presenter 1 and 2.
