Harvard:Biophysics 242r/2011: Difference between revisions

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==Course overview==
*Graduate level seminar focusing on in-silico design pipelines for nucleic acid- and protein-based molecular machinery and programmable molecular systems. Students are mentored to produce substantial midterm and final group design projects.
*No formal prerequisites. Projects are tailored to each student's strengths and interests.
<br>
<br>
==Course overview==


==Example topics for final design project==
*'''Artificial chemotactic swimmers'''
*'''Nonequilibrium networks of nano-machines mimicking dynamic instability in the cytoskeleton'''
*'''Nucleic acid logic automata responsive to microRNAs in serum'''
*'''Self-assembled solar energy harvester based on bio-inorganic nano-antennae for uv-vis'''
*'''Systematic debugging of DNA labeling chemistries by atomic-resolution TEM imaging of DNA origami'''
*'''Light-controlled transcriptional activation and repression through rational molecular design'''
*'''Directed evolution of tissue engineering scaffold nano-materials'''
*'''Programmable multistep chemical synthesis by templating on nanostructures'''
*'''Ultra-sensitive molecular signal processing for synthetic biology'''
*'''Synthetic nanostructure - virus conjugates'''
*'''Nano-breadboards for probing electron transport in proteins'''
*'''Replication of information in synthetic crystals'''
*'''Etc.'''


==Potential course projects==
<br>
'''Self-assembled solar energy harvester'''
 
'''Massively parallel mechanical force measurement system'''


==Logistics==
==Logistics==
*Meeting time: Tuesdays and Thursdays, 10:00—11:30 am
*Meeting time: 2011 Spring Term, Mondays and Wednesdays, 100 pm — 230 pm, with optional sessions for working on projects from 230 pm to 330 pm, starting on Monday, February 7
* [http://www.college.harvard.edu/calendar.html First class] DATE AND TIME OF FIRST CLASS
*Form teams for midterm projects on Monday, February 7
*Location: LOCATION
*Form teams for final projects on Monday, March 21
* [http://www.college.harvard.edu/calendar.html First class] on Monday, January 24
*Location: CLSB521
*No exams
*No exams
*No prerequisites
*Prerequisites: none
*Grading
*Grading
**25% Participation
**33% Participation
**25% Midterm project
**33% Midterm project
**50% Final project
**33% Final project
*[http://isites.harvard.edu/icb/icb.do?keyword=k74783&pageid=icb.page.inlinecontent.icb.page375264.icb.page375264 Harvard course site]
*[[Harvard:Biophysics_242r/2011/Course Development Log]]<br>
 
<br>


==Background Info and previous class projects==
==Background Info and previous class projects==
*http://openwetware.org/wiki/Biophysics_242r/2009
*http://openwetware.org/wiki/Biophysics_242r/2009
<br>


==Recent changes==
==Recent changes==

Latest revision as of 01:28, 13 December 2010

Biophysics 242r/2011

Biologically Inspired Molecular Engineering

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Course overview

  • Graduate level seminar focusing on in-silico design pipelines for nucleic acid- and protein-based molecular machinery and programmable molecular systems. Students are mentored to produce substantial midterm and final group design projects.
  • No formal prerequisites. Projects are tailored to each student's strengths and interests.


Example topics for final design project

  • Artificial chemotactic swimmers
  • Nonequilibrium networks of nano-machines mimicking dynamic instability in the cytoskeleton
  • Nucleic acid logic automata responsive to microRNAs in serum
  • Self-assembled solar energy harvester based on bio-inorganic nano-antennae for uv-vis
  • Systematic debugging of DNA labeling chemistries by atomic-resolution TEM imaging of DNA origami
  • Light-controlled transcriptional activation and repression through rational molecular design
  • Directed evolution of tissue engineering scaffold nano-materials
  • Programmable multistep chemical synthesis by templating on nanostructures
  • Ultra-sensitive molecular signal processing for synthetic biology
  • Synthetic nanostructure - virus conjugates
  • Nano-breadboards for probing electron transport in proteins
  • Replication of information in synthetic crystals
  • Etc.


Logistics

  • Meeting time: 2011 Spring Term, Mondays and Wednesdays, 100 pm — 230 pm, with optional sessions for working on projects from 230 pm to 330 pm, starting on Monday, February 7
  • Form teams for midterm projects on Monday, February 7
  • Form teams for final projects on Monday, March 21
  • First class on Monday, January 24
  • Location: CLSB521
  • No exams
  • Prerequisites: none
  • Grading
    • 33% Participation
    • 33% Midterm project
    • 33% Final project
  • Harvard course site
  • Harvard:Biophysics_242r/2011/Course Development Log


Background Info and previous class projects


Recent changes

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26 April 2024

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25 April 2024

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