Hoatlin Lab: Difference between revisions
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'''Lab News''' | |||
;For news, follow the [http://twitter.com/HoatlinLab Hoatlin lab Twitter] | |||
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Our laboratory is interested in understanding the molecular function of the Fanconi anemia (FA) protein network in context with other proteins that regulate or influence genomic stability. Fanconi anemia is a rare genetic disease that is typically associated with developmental abnormalities, bone marrow failure and increased risk of cancer. Because the majority of the FA proteins are unique with no significant homologies, we expect the results of our studies to shed new light on fundamental mechanisms that control the integrity of the human genome and influence cancer susceptibility. The FA pathway is part of a network of proteins that contains BRCA2 and two other recently identified FA genes (FANCN and FANCJ) that influence breast cancer susceptibility. Ultimately, insights into the mechanism of the FA/BRCA network of proteins will lead to an understanding of the underlying molecular defect in FA and may lead to more effective avenues of treatment for this devastating pediatric disease and cancer. | |||
We work in [[Hoatlin:Portland Oregon| Portland, Oregon]] at [http://www.ohsu.edu/ OHSU], in the [http://www.ohsu.edu/biochem/ Department of Biochemistry & Molecular Biology] and the [http://www.ohsucancer.com/ OHSU Knight Cancer Institute]. | |||
==Teaching Links== | |||
*Our lab's Fanconi Anemia antibodies are available from [http://www.novusbio.com Novus Biologicals] and soon by Millipore. | |||
[http://openwetware.org/wiki/CANB_610 Advanced Topics in Cancer Biology (CANB 610)] | |||
[[Hoatlin:OHSU_Genetic_Mechanisms_Class| Genetic Mechanisms Class (CON662)]] | |||
[[Hoatlin:OHSU Replication, Recombination and Repair (R3) Club| OHSU DNA Replication, Recombination and Repair (R3) Club]]. | [[Hoatlin:OHSU Replication, Recombination and Repair (R3) Club| OHSU DNA Replication, Recombination and Repair (R3) Club]]. | ||
[[Hoatlin: | [[Hoatlin: CSF|Med Students Fundamentals]] | ||
==Classes of the past== | |||
[[BMCB625|Advanced Topics in Molecular Biology(BMB625)]] | [[BMCB625|Advanced Topics in Molecular Biology(BMB625)]] | ||
Revision as of 06:47, 19 August 2014
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