IGEM:Harvard/2006/DNA nanostructures: Difference between revisions
From OpenWetWare
Jump to navigationJump to search
ShawnDouglas (talk | contribs) mNo edit summary |
ShawnDouglas (talk | contribs) |
||
| Line 14: | Line 14: | ||
==Container Designs== | ==Container Designs== | ||
<gallery> | <gallery> | ||
Image:Igemharv06_Katie_Val_cylinder1.gif|[[IGEM:Harvard/2006/Container Design 1|Design 1]] | Image:Igemharv06_Katie_Val_cylinder1.gif|[[IGEM:Harvard/2006/Container Design 1|Design 1]]<br>hexagonal core, separate 1-ply lids | ||
Image:Smallcontainer2.jpg|[[IGEM:Harvard/2006/Container Design 2|Design 2]] | Image:Smallcontainer2.jpg|[[IGEM:Harvard/2006/Container Design 2|Design 2]]<br>hexagonal core, separate 2-ply lids | ||
Image:Igemharv06_msmrect.png|[[IGEM:Harvard/2006/Container Design 3|Design 3]] | Image:Igemharv06_msmrect.png|[[IGEM:Harvard/2006/Container Design 3|Design 3]]<br>rectangular core, continuous 1-ply lids | ||
</gallery> | </gallery> | ||
==Coding== | ==Coding== | ||
Revision as of 19:57, 21 June 2006
Project Overview
- Our goal is to to design and implement molecular containers, which can be dynamically opened and closed by an external stimulus.
- The containers will be implemented as DNA nanostructures, which afford a significant degree of positional control and chemical versatility.
- As an initial proof-of-concept, we plan to use our DNA containers to demonstrate controllable activation ("delivery") of anti-thrombin aptamers.
- We expect that molecular containers could have several interesting scientific and clinical applications, such as
- Drug and gene delivery
- Bio-marker scavenging (early detection of biomarkers)
- Directed evolution (compartmentalized selections)
- Using multiplexing for combinatorial chemical synthesis
- Capture and stabilization of multiprotein complexes
- Protein folding (chaperones)
- Cell sorting
Container Designs
-
Design 1
hexagonal core, separate 1-ply lids -
Design 2
hexagonal core, separate 2-ply lids -
Design 3
rectangular core, continuous 1-ply lids
