IGEM:PennState/Labbook/Nimrah Ahmed/2008/05/28: Difference between revisions
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== | ==PPAR & Thalates== | ||
* | *Reference material on CMS. Lots of it. | ||
Briefly: | |||
*Peroxisomes are subcellular organelles, found in | |||
most animal cells, that perform diverse metabolic | |||
functions, including H2O2-derived respiration, boxidation | |||
of fatty acids, and cholesterol metabolism | |||
(Lock et al., 1989). | |||
*Peroxisome proliferator | |||
chemicals (PP) are a large class of structurally | |||
dissimilar industrial and pharmaceutical products | |||
that were originally identified as inducers of | |||
peroxisomes in the livers of exposed mice and | |||
rats. | |||
*A subset of nuclear receptor superfamily members | |||
called peroxisome proliferator-activated receptors | |||
(PPAR) play pivotal roles in mediating | |||
many, if not all, of the adaptive consequences of | |||
PP exposure. PP activate PPAR in most cases by | |||
binding directly to the receptor, leading to the | |||
altered regulation of genes involved in lipid | |||
metabolism and peroxisome proliferation, as well | |||
as genes involved in determining cell fate (Corton | |||
et al., 2000). | |||
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PPAR & Thalates
Briefly:
most animal cells, that perform diverse metabolic functions, including H2O2-derived respiration, boxidation of fatty acids, and cholesterol metabolism (Lock et al., 1989).
chemicals (PP) are a large class of structurally dissimilar industrial and pharmaceutical products that were originally identified as inducers of peroxisomes in the livers of exposed mice and rats.
called peroxisome proliferator-activated receptors (PPAR) play pivotal roles in mediating many, if not all, of the adaptive consequences of PP exposure. PP activate PPAR in most cases by binding directly to the receptor, leading to the altered regulation of genes involved in lipid metabolism and peroxisome proliferation, as well as genes involved in determining cell fate (Corton et al., 2000).
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