Jacobs
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Welcome to the Cell and Molecular Biomechanics Lab at Columbia University! The CMBL is focused on determining the mechanism that allows cells to sense and respond to extracellular mechanical stimulation. Particularly we are interested in determining, at a cellular level, how bone tissue is regulated by physical loading. This work has applications in developing new therapies to age-related bone loss and osteoporosis. We explore this question both in cell culture identifying novel molecular targets and in quantifying the skeletal sensitivity to loading of tissue-specific conditional deletions in mice. Our current targets include focal adhesions, cytoskeletal proteins, and the cell's primary cilium.
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26 April 2024
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08:43 (cur | prev) +16,816 Xning098 talk contribs (Created page with "{{Template:CHEM-ENG590E}} ==Introduction== Microfluidics is the science and technology of systems that process or manipulate small (10 <sup> -18 </sup> to 10 <sup>−18 </sup> litres) amounts of fluids, using channels with dimensions of tens to hundreds of micrometres, as stated by George Whitesides. <sup> https://doi.org/10.1038/nature05058 1 </sup>. Microfluidic devices are microchemical systems such as labs on the chip, organs on the chip and plants on the chip....") |
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