Karenliu: Difference between revisions
No edit summary |
No edit summary |
||
Line 12: | Line 12: | ||
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. | In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists. | ||
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog ''Xenopus laevis'' and the mouse. ''Xenopus'' embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using ''Xenopus'' to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β. | The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog ''Xenopus laevis'' and the mouse. ''Xenopus'' embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using ''Xenopus'' to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β. |
Revision as of 00:29, 18 May 2007
The Liu Lab | Department of Craniofacial Biology | Kings College London |
Home | Research | Publications | Protocols & Etc. | Lab Members | Contact Us | Links |
Welcome to the Liu lab!
We are interested in signal transduction in developmental biology.
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists.
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse. Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems. In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
<wikionly>
Recent updates to the lab wiki
- N
- This edit created a new page (also see list of new pages)
- m
- This is a minor edit
- b
- This edit was performed by a bot
- (±123)
- The page size changed by this number of bytes
7 May 2024
14:02 | Biophysics Lab:Lab Members diffhist +573 Elizabeth Suesca talk contribs |
13:44 | User:Elizabeth Suesca diffhist +317 Elizabeth Suesca talk contribs (→Publications) |
13:38 | Balazsi Lab diffhist +13 Gabor Balazsi talk contribs |
|
12:41 | BioMicroCenter:Covaris 2 changes history +1 [Noelani Kamelamela (2×)] | |||
|
12:41 (cur | prev) +8 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:40 (cur | prev) −7 Noelani Kamelamela talk contribs (→R230) |
09:48 | CHIP:Talks diffhist +701 Gabor Balazsi talk contribs |
6 May 2024
|
12:59 | BioMicroCenter:Covaris 11 changes history +450 [Noelani Kamelamela (11×)] | |||
|
12:59 (cur | prev) −17 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:58 (cur | prev) −1 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:57 (cur | prev) +1 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:57 (cur | prev) +6 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:56 (cur | prev) +2 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:55 (cur | prev) +6 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:54 (cur | prev) −1 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:54 (cur | prev) +64 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:49 (cur | prev) +49 Noelani Kamelamela talk contribs (→R230) | ||||
|
12:22 (cur | prev) +221 Noelani Kamelamela talk contribs (→R230) | ||||
|
11:55 (cur | prev) +120 Noelani Kamelamela talk contribs (→R230) |
11:41 | Paper Microfluidic Device for Archiving Breast Epithelial Cells diffhist −89 Xning098 talk contribs (→Paper Microfluidics) |
5 May 2024
21:12 | Upload log Xning098 talk contribs uploaded File:Whatman® FTA® cards.png |
<nonwikionly> This page was created using Open Wetware.</nonwikionly>