User:Tkadm30/Notebook/Research

Research Interests

• Neuroinflammation of the hippocampus/CNS
• Glutamatergic system/neurotransmission
• Glutamate neurotoxicity
• Astrocytes/mitochondria
  • CB1 expression in hippocampal astrocytes and mitochondria
• Intracellular DHA delivery to neurons
• Neuroprotective effects of P2X7 receptor inhibition
  • Extracellular ATP releases
  • ATP-mediated gliotransmission
• Neuroprotection by endocannabinoids of the hippocampus
  • Adult hippocampal neurogenesis
  • Endocannabinoid-mediated neuroprotection agaisnt synthetic neurotoxicants of the CNS.

Endocannabinoids as a novel therapeutic platform

The neuropsychological aspects of endocannabinoid based neuroprotection has emerged as a mature research area. My current research aim to investigate methods for exploiting the endocannabinoids platform for neurocognitive therapy.

Intracellular delivery of synaptamide to neurons by endocannabinoids

This notebook propose a experimental method for delivery of DHA to hippocampal stem/progenitor cells using endocannabinoid-mediated retrograde signaling.

• Endocannabinoid Notebook

Synaptogenic effects of DHA on neurotransmission, a putative endocannabinoid induced by THC

P2X7 receptor mediate synaptogenic DHA signaling and intracellular signal transduction pathways relevant to PPAR-induced neural differentiation. Hence, intracellular THC delivery may induce PPAR-dependent pathways for DHA-mediated neural differentiation and proliferation of hippocampal progenitor cells through modulation of P2X7 receptor.

• DHA Notebook
• P2X7 Notebook
• THC Notebook

Programming of hippocampal progenitor cells by anandamide trafficking

• Anandamide Notebook