CHE.496/2009/Planning

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Arsenic sequestration

Strategies


Pathway

Genes

  • arsA
  • arsB
    • arsenite/antimonite transporter [ Escherichia coli str. K-12 substr. DH10B ]
    • GeneID: 6062297
  • arsC
    • arsenate reductase [ Escherichia coli str. K-12 substr. DH10B ]
    • GeneID: 6058451
    • Protein: Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.

References

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