Daniël is a fifth year PhD student from the Biochemical, Molecular, Cellular and Developmental Biology (BMCDB) Graduate Group and he is a shared student with Ian Korf. Daniël is also a member of the Designated Emphasis in Biotechnology, and was a recipient of the NIH training grant in Biomolecular Technology.
Daniël joined the lab in Spring of 2009, and his research project is focused on the evolution of the centromere tandem repeat sequences in over 300 eurkaryotes using bioinformatics.
Daniël received his BSc and MSc from Leiden University in the Netherlands. For his MSc he worked in Dr. Lipsky's lab at the NIH, studying the B lymphocyte immunoglobulin heavy chain repertoire. For his MSc thesis, Daniël worked in Prof. Dr. de Kloet's lab at the LACDR / Leiden University identifying SNPs in the mineralocorticoid receptor promoter of different inbred mouse strains. Following his MSc he moved to San Francisco where Daniël joined Dr. Pearce's lab at UCSF, working on understanding the signaling cascade regulation sodium reabsorption in kidney epithelium cells upon aldosterone treatment. His work has led to three publications:
- Melters DP, Paliulis LV, Korf IF, Chan SW. 2012 Holocentric chromosomes: convergent evolution, meiotic adaptations, and genomic analysis. Chromosome Res. [Epub ahead of print] link
- Soundararajan R, Wang J, Melters DP, Pearce D. 2010 Glucocorticoid-induced leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J. Biol. Chem. 285(51):39905-13. link
- Soundararajan R, Melters DP, Shih IC, Wang J, Pearce D. 2009 Epithelial sodium channel regulated by differential composition of a signaling complex. Proc. Natl. Acad. Sci. U.S.A. 106(19):7804-7809. link
- Soundararajan R, Wang J, Melters DP, Pearce D. 2007 Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J. Biol. Chem. 282(50):36303-13. link
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Daniël also founded and moderates the BMCDB graduate group blog BMCDB blog