Codon pairs

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Apparently there is nonrandom codon pair utilization in many species. Codon pairs may affect translational elongation rates and therefore protein production. (There can be translational pause sites that are species-specific.)

CODA genomics checks and optimizes for such things.

(Note: I haven't read the papers to evaluate this claim. Just posting the info here so that I remember it.)

References

  1. Gutman GA and Hatfield GW. . pmid:2657727. PubMed HubMed [Gutman-PNAS-1989]
  2. Irwin B, Heck JD, and Hatfield GW. . pmid:7559409. PubMed HubMed [Irwin-JBC-1995]
  3. Trinh R, Gurbaxani B, Morrison SL, and Seyfzadeh M. . pmid:14644097. PubMed HubMed [Trinh-MolImmun-2004]
All Medline abstracts: PubMed HubMed
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