Endy:Computational modeling of demand/Parameterization

From OpenWetWare

Jump to: navigation, search
Add to My Links

Cytoplasmic nucleotide levels

It is hard to measure the cytoplasmic levels of free NTPs. Several groups have tried to make these measurements when studying the growth rate dependence of rRNA synthesis [1, 2]. Both of these groups calculated nucleotide levels per unit absorbance. Liang et al.[3] used this data to estimate that cytoplasmic ATP levels are in the range of 10mM. That corresponds to ~1e7 of each nucleotide per cell. For the moment, I'm going to use this value in my model.

References

Error fetching PMID 10660546:
Error fetching PMID 9405339:
Error fetching PMID 10493854:
  1. Error fetching PMID 10660546: [Petersen]
  2. Error fetching PMID 9405339: [Gaal]
  3. Error fetching PMID 10493854: [Liang]
All Medline abstracts: PubMed HubMed
Personal tools