Hexlab
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HeX Laboratory
Tongji Medical College(TJMC),HUST
We are a computational biology laboratory interested in the following area:
- Investigation on the regulation of gene expression from a large amount of genomic, epigenomic, and transcriptomic data using bioinformatic approach;
- Identification of the role of gene regulation in developmental disorders and diseases.
- Genomics and epigenomics on cardiac regeneration and stem cells.
- The long-term goal is to identify the correlation of the genomic and epigenomic information with development and disease (especially cancer) and to translate the findings into prognosis, diagnosis and clinical treatment.
Recent news:
March, 2024:
- A manuscript collaboration with Hongxu Pu in Dr. Xiao's lab at Tongji Hospital,TJMC,HUST, titled "Single cell transcriptome profiling of infrapatellar fat pad highlights the role of interstitial inflammatory fibroblasts in osteoarthritis" has been accepted for publication by the International Immunopharmacology journal doi:10.1016/j.intimp.2024.111888. Cheers!
- A manuscript of Ying Yin's collaboration with Dr. Zhou's lab at Institute of Reproductive Health, TJMC, HUST, titled "Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice" has been accepted for publication by the Advanced Science journal doi:10.1002/advs.202308018. Cheers!
February, 2024:
- A manuscript of Miaomiao Zhu's collaboration with Ziwen Cai in Dr. Dong's lab at Wuhan Union Hospital,TJMC,HUST, titled "Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells" has been accepted for publication by the Circulation journal doi:10.1161/CIRCULATIONAHA.123.065143. Cheers!
January, 2024:
- A manuscript of Qingchuan Chen's collaboration with Jiaojuan Huang in Dr. Yang's lab at Department of Medical Genetics, School of Basic Medicine,TJMC,HUST, titled "Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis", has been accepted for publication by the RNA journal doi: 10.1261/rna.079865.123. Cheers!
- A manuscript titled "Investigating the Potential Shared Molecular Mechanisms between COVID-19 and Alzheimer's Disease via Transcriptomic Analysis" of our lab, with Yixian Fan as the first author, has been published by the Viruses journal doi: 10.3390/v16010100. Cheers!
November, 2023:
- A manuscript of Qian Zhou's collaboration with Yunan Wang in Dr. Wu's lab at Department of Immunology, School of Basic Medicine,TJMC,HUST, titled "Cell volume controlled by LRRC8A-formed volume-regulated anion channels fine-tunes T cell activation and function", has been published by the Nature Communications journal doi: 10.1038/s41467-023-42817-y. Cheers!
October, 2023:
- A manuscript of Xiaozhao Liu's collaboration with Hanxiao Wang in Dr. Yi's lab at Department of Forensic Medicine,TJMC,HUST, titled "Identification of Mixtures of Two Types of Body Fluids Using the Multiplex Methylation System and Random Forest Models", has been published by the Current Medical Science journal doi: 10.1007/s11596-023-2770-1. Cheers!
May, 2023:
- A manuscript of Qian Zhou's collaboration with Feng Liu in Dr. Chen's lab at School of Basic Medicine,TJMC,HUST, titled "Piperlongumine conquers temozolomide chemoradiotherapy resistance to achieve immune cure in refractory glioblastoma via boosting oxidative stress-inflamation-CD8+-T cell immunity", has been published by the Journal of Experimental & Clinical Cancer Research journal DOI:10.1186/s13046-023-02686-1. Cheers!
February, 2023:
- A manuscript titled "Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic and adult mammalian heart" of our lab, with Miaomiao Zhu and Huamin Liang as co-first authors, has been accepted for publication by the Frontiers of Medicine journal DOI: 10.1007/s11684-023-0987-9. Cheers!
September, 2022:
- A manuscript of Ying Yin and Xiaozhao Liu's collaboration with Dr. Zhou's lab at Institute of Reproductive Health, TJMC, HUST on "Transcriptome and Methylome of peripheral blood samples form 3-months recovery of COVID-19" has been accepted for publication by the Frontiers in Cell and Developmental Biology journal doi: 10.3389/fcell.2022.1001558. Cheers!
March, 2022:
- A manuscript of Miaomiao Zhu's collaboration with Chao Zhang in Dr. Dong's lab at Wuhan Union Hospital,TJMC,HUST on transcriptomic landscape in human end-stage heart failure has been published by the iScience journal DOI:10.1016/j.isci.2022.103935. Cheers!
December, 2021:
- A manuscript of Yuting Dong and Xiaozhao Liu's collaboration with Dr. Wang's lab at Guangxi Medical University on DNA methylation effects on alternative promoter usage in HCC has been accepted for publication by the Frontiers in Oncology journal Abstract. Cheers!
November, 2021:
- A manuscript of Qian Zhou's collaboration with Hong Cao in Dr. Dong's lab at Wuhan Union Hospital,TJMC,HUST on MDK preventing CAVD has been accepted for publication by the Frontiers in Cell and Developmental Biology journal DOI:10.3389/fcell.2021.794058. Cheers!
January, 2021:
- A manuscript of Ying Yin's collaboration with Dr. Zhou's lab at Institute of Reproductive Health, TJMC, HUST on Interaction Between Coronavirus and Retrotransposon has been accepted for publication by the Frontiers in cellular and infection microbiology journal PMID: 33732659. Cheers!
December, 2020:
- A manuscript of Qian Zhou's collaboration with Chenghao Gao in Dr. Xiao's lab at Tongji Hospital,TJMC,HUST on chondrocytes by scRNA-seq has been accepted for publication by the Aging journal PMID: 33879632. Cheers!
March, 2020:
- A manuscript of Jing Jin's collaboration with Dr. Silva's lab at Georgetown University on sisRNAs has been accepted for publication by the BMC Genomics journal PMID: 32264855. Cheers!
January, 2020:
- An invited review by Yixian Fan on The impact factors of 3D genome organization has been accepted for publication by the Scientia Sinica Vitae (中国科学. 生命科学) journal DOI: 10.1360/SSV-2019-0218. Cheers!
November, 2017:
- Dr. Huamin Liang has joined the lab as an Associate Professor. She is an biologist/doctor on physiology (cardiac regeneration and stem cells) and received her Dr. rer. Med degree in physiology from Cologne University in Germany, Welcome!
- A manuscript is accepted by the Biochemistry journal PMID: 29072898, Ximiao conducted the bioinformatics analysis and is the co-author. Cheers!
October, 2017:
- Ms. Lijia Zhu from TJMC, HUST will be an undergraduate intern in our lab, and she is an M.D.-Ph.D. candidate and will conduct her research project in our lab next two years, welcome!
- Mr. Zhe Li from TJMC, HUST will be an undergraduate intern in our lab, and he is an M.D.-Ph.D. candidate and will conduct his research project in our lab next two years, welcome!
- Mr. Zi-Xuan Guo from TJMC, HUST will be an undergraduate intern in our lab, and he is a B.S. candidate and will conduct his research project in our lab, welcome!
July, 2017:
- Ms. Ruo-Qiao Chen from TJMC, HUST will be an undergraduate intern in our lab, and she is a B.S. candidate and will conduct her research project in our lab, welcome!
- Dr. Ximiao He has been appointed as the Director of Department of Physiology, School of Basic Medicine, TJMC, HUST. Cheers!
June, 2017:
- Ms. Xiaofei Deng from Department of Immunology, School of Basic Medicine, TJMC, HUST will be a guest student in our lab, and she is a Master student (Mentor: Dr. Xiangping Yang) majored in Immunology. Welcome!
- Mr. Cai Zhang from Department of Immunology, School of Basic Medicine, TJMC, HUST will be a guest student in our lab, and he is a Ph.D candidate (Mentor: Dr. Xiangping Yang) majored in Immunology. Welcome!
May, 2017:
- Dr. Ximiao He was selected in the 13 batch of the "1000 Talents Program for Young Scholars". Cheers!
- Ms. Yixian Fan from TJMC,HUST will be a graduate student (Ph.D candidate) in our lab, and her major will be Genomics and Bioinformatics, welcome!
April, 2017:
- Ms. Yufen Zhang from Department of Pathophysiology, School of Basic Medicine, TJMC, HUST will be a guest student in our lab, and she is a Ph.D candidate (Mentor: Dr. Youming Lu) majored in Pathophysiology, welcome!
- Ms. Ke Xiao from Department of Pathophysiology, School of Basic Medicine, TJMC, HUST will be a guest student in our lab, and she is a Ph.D candidate (Mentor: Dr. Youming Lu) majored in Pathophysiology, welcome!
- Mr. Liangjun Wu from Department of Forensic Medicine,TJMC, HUST will be a guest student in our lab, and he is an MD-Ph.D candidate (Mentor: Dr. Bo Xiong) majored in forensic medicine, welcome!
- Ms. Jincheng Li from Zhengzhou University will be a graduate student in our lab, and her major will be Genomics and Bioinformatics, welcome!
March, 2017:
- A manuscript is accepted by the BMC Cardiovasc Disorder journal PMID: 28249620, Ximiao conducted the analysis for this project and is jointly co-correspondence author, Cheers!
- Mr. Jinfu Sun from TJMC, HUST will be an undergraduate intern in our lab, and he is an M.D.-Ph.D. candidate and will conduct his research project in our lab next two years, welcome!
February, 2017:
- Dr. Shiliang Hu has joined the lab. He is a Ph.D of Genomics, and received his Ph.D. from University of Trento, Italy, Welcome onboard!
January, 2017:
- Dr. Jing Jin has joined the lab as a postdoc (Jointly with Prof. Lu). She is a biologist on neuroscience and received her Ph.D. from Georgetown University, USA, Welcome onboard!
December, 2016:
- A manuscript is accepted by the Biochemistry journal PMID: 27951657, Ximiao conducted the bioinformatics analysis and is the 2nd author. Cheers!
- A manuscript is accepted by the Bioinform Biol Insights. journal PMID:27980397 , which is an invited review. Cheers!
November, 2016:
- Dr. Ximiao He has been appointed as Director of Center for Genomic & Proteomic Research, School of Basic Science, TJMC, HUST. Cheers!
- A manuscript is accepted by the Front Mol Biosci. journal PMID: 27900321, Ximiao conducted RNA-Seq analysis and motif search analysis and is a co-author. Cheers!
- Mr. Jingzhi Yang from TJMC, HUST will be an undergraduate intern in our lab, he is an M.D.-Ph.D candidate and will conduct his research project in our lab next two years, welcome!
- The HeX Lab is on the way.
