Kristoffer Chin: Week 5
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Question
The question we are asking for week 5 is if there are specific differences nucleotide sequences that cause an increase in the rate of CD4 T cells decline in rapid progressors compared to non-progressors.
Hypothesis
We believe that there will be a difference in the nucleotide sequences found in the nucleotide sequences in rapid progressors and non-progressors
Subjects
- For the group of rapid progressors, we have chosen 4-V2, 4-V3, 4-V4, 10-V4, 10-V5, 10-V6, 11-V2, 11-V3, 11-V4. These subjects were chosen because they had the highest frequencies of visit which allowed a better variable of CD4 T cells to choose from. These specific visits were chosen because they had the highest rate of CD4 T Cell decline
- For the group of non-progressors, we have chosen 2-V1, 2-V3, 2-V4, 12-V3, 12-V4, 12-V5, 13-V2, 13-V3, 13-V5. These subjects were chosen because they were the only recorded nonprogressors in the experiment. These visits were chosen because they had the highest CD4 T cell count among all visits.
- All clones will also be analyzed for each visit to find a difference in the nucleotide sequence.
Journal articles
- Borrego P, Marcelino JM, Rocha C, Doroana M, Antunes F, Maltez F, Gomes P, Novo C, Barroso H, and Taveira N. . pmid:18778482.
- Hill MD and Hernández W. . pmid:16385396.
- Templeton AR, Reichert RA, Weisstein AE, Yu XF, and Markham RB. . pmid:15342497.
- Deckers R, Quesson B, Arsaut J, Eimer S, Couillaud F, and Moonen CT. . pmid:19164593.
- Deckers R, Quesson B, Arsaut J, Eimer S, Couillaud F, and Moonen CT. . pmid:19164593.
BIOL398-01: Bioinformatics Lab
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