Welcome to the Molecular Genetics of Plant Stress Tolerance Lab (Ruben Alcazar) at the Department of Biology, Healthcare & Environment of the University of Barcelona.
We're a recently created research group that investigates the adaptation of plants to local environments. We focus on the evolutionary adaptation of plant populations to abiotic and biotic stresses, which are major challenges for plant survival under the current climate change predictions. Derived from our research, we investigate ways for improving stress protection.
For a more detailed view of our research, please have a look at our Research Projects and Scientific Publications sections. You can follow an updated list of our activities and publications in the NEWS section below. For any other enquires, do not hesitate to contact us directly.
Info currently available in the following languages:
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1. MOLECULAR EVOLUTION OF DISEASE RESISTANCE IN PLANTS (R.Alcázar)
In our lab, we make use of the extensive natural variation of Arabidopsis thaliana populations to answer key fundamental questions:
- How plants adapt to local environments including the microbiota?
- How plants maintain variability of genes involved in pathogen recognition and to which extent this variability is caused by the interaction with pathogens?
- How the environment manipulates immune responses? How this affects the above points?
To address these and other questions, we (and others) developed a new model for plant immunity studies based on the use of Arabidopsis immune-related incompatible hybrids. These are hybrids obtained by crosses of natural Arabidopsis accessions that exhibit constitutive activation of defense, stunted growth and sterility in the absence of pathogen challenge. Often, such phenotypes are temperature-dependent and suppressed at high temperature.
These genetic interactions might unravel molecular partners required for proper modulation of defense. Some of these cases are background-dependent and therefore, likely difficult to be observed in classical reference accessions.
Since some years, we're using the Ler / Kas-2 immune-related hybrid incompatibility as molecular model to answer some of the questions above. The Landsberg (from Gorzów Wielkopolski, Poland)/Kashmir-2 (from Kashmir mountains) incompatibility involves populations in Central Europe and Central Asia which enable to expand our analyses to population scales. We apply population genetics on top of our molecular and biochemical analyses.
Derived from our research, we attempt to provide new strategies for crop protection at medium to long-term.
2. Polyamines and plant stress protection (R. Alcázar and Antonio F. Tiburcio)
Polyamines are small amines present in living organisms. Polyamines are essential for cell viability and have co-evolved and participate in developmental and stress signalling pathways. We’re interested to know how polyamines exert their functions in plants, with a focus on stress tolerance. For this, we’re applying modern genetics, genomics and evolutionary biology. Our final goal is to provide new strategies for crop protection against different types of stress. Read our latest publication on this topic here. Most cited review (>450 times) here
ACADEMIC PRESS RELEASES
Alcázar Lab work highlighted by the University of Barcelona 20.01.15
Rubén Alcázar research highlighted by the Faculty of Pharmacy at UB, January 2015
Alcázar Lab work highlighted by the Bulletin of the Spanish Society of Plant Physiology, SEFV. January, 2015
PLoS Genet 2014 highlight by Max Planck Institute, Cologne. 11.12.14.
Arabidopsis semidwarfs: the green revolution in nature 02.12.2013. University of Barcelona.
Hybrid plants with over-reactive immune system 17.11.2010. Max Planck Society.
Rubén Alcázar is Ramón y Cajal Researcher at the Department of Biology, Healthcare and Environment of the University of Barcelona.
Research in Alcázar Lab is supported by:
- 7th Framework Programme. Marie Curie Career Integration Grant (DISEASENVIRON, PCIG10-GA-2011-303568) of the European Union.
- Ramón y Cajal Program (RYC-2011-07847) of the Ministerio de Ciencia e Innovación (Spain).
- BFU2013-41337-P grant of the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia (Ministerio de Economía y Competitividad, Spain).