Synthetic Biology:Connotea
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All articles tagged with "synthetic biology" from connotea are automatically listed here.
| bibtexCitation | bibtexEntryType | author | title | journal | year | month | day | volume | issue | pages | keywords | note | issn | url | abstract |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Benner2005a | article | Benner, Steven A. ; Sismour, A. Michael | Synthetic biology | Nature reviews. Genetics. | 2005 | Jul | xx | 6 | 7 | 533--543 | synthetic biology | 10.1038/nrg1637 | 1471-0056 | http://www.nature.com/nrg/journal/v6/n7/abs/nrg1637.html | |
| Brenner2008 | article | Brenner, Katie ; You, Lingchong ; Arnold, Frances H. | Engineering microbial consortia: a new frontier in synthetic biology. | Trends in biotechnology | 2008 | Jul | 31 | biotechnology | 10.1016/j.tibtech.2008.05.004 | 0167-7799 | http://www.ncbi.nlm.nih.gov/pubmed/18675483 | ||||
| Kodumal2004 | article | Kodumal, Sarah ; Patel, Kedar ; Reid, Ralph ; Menzella, Hugo ; Welch, Mark ; Santi, Daniel | Total synthesis of long DNA sequences: Synthesis of a contiguous 32-kb polyketide synthase gene cluster | Proceedings of the National Academy of Sciences of the United States of America | 2004 | Nov | 02 | 101 | 44 | 15573--15578 | synthetic biology | 10.1073/pnas.0406911101 | http://www.pnas.org/content/101/44/15573.abstract | ||
| Hammann2007 | article | Hammann, Christian ; Westhof, Eric | Searching genomes for ribozymes and riboswitches | Genome Biology | 2007 | Apr | 30 | 8 | 4 | 210 | synthetic biology | 10.1186/gb-2007-8-4-210 | http://genomebiology.com/2007/8/4/210 | ||
| Arkin2008 | article | Arkin, Adam | Setting the standard in synthetic biology | Nat Biotech | 2008 | Jul | xx | 26 | 7 | 771--774 | OPINION | 10.1038/nbt0708-771 | http://www.nature.com/nbt/journal/v26/n7/full/nbt0708-771.html | ||
| Church2005a | article | Church, George | Let us go forth and safely multiply | Nature | 2005 | Nov | 24 | 438 | 7067 | 423 | synthetic biology | 10.1038/438423a | 0028-0836 | http://dx.doi.org/10.1038/438423a | |
| Check2005a | article | Check, Erika | Synthetic biology: Designs on life | Nature | 2005 | Nov | 24 | 438 | 7067 | 417--418 | synthetic biology | 10.1038/438417a | http://dx.doi.org/10.1038/438417a | ||
| Pryciak2008 | article | Pryciak, Peter | SYSTEMS BIOLOGY: Customized Signaling Circuits | Science | 2008 | Mar | 14 | 319 | 5869 | 1489--1490 | signalling | 10.1126/science.1156414 | http://www.sciencemag.org/cgi/content/full/319/5869/1489?ck=nck | ||
| ref9 | article | Rewiring Bacteria, Two Components at a Time | Cell | 2008 | xx | xx | 133 | 6 | 947 | synthetic biology | 10.1016/j.cell.2008.05.035 | 00928674 | http://dx.doi.org/10.1016/j.cell.2008.05.035 | ||
| Greber2007 | article | Greber, David ; Fussenegger, Martin | Mammalian synthetic biology: Engineering of sophisticated gene networks | Journal of Biotechnology | 2007 | Jul | xx | 130 | 329--345 | Biopharmaceutical manufacturing | 10.1016/j.jbiotec.2007.05.014 | http://www.sciencedirect.com/science/article/B6T3C-4NT9G60-6/1/be91f43dd87b2e4e80afa221d5ffbc18 | With the recent development of a wide range of inducible mammalian transgene control systems it has now become possible to create functional synthetic gene networks by linking and connecting systems into various configurations. The past 5 years has thus seen the design and construction of the first synthetic mammalian gene regulatory networks. These networks have built upon pioneering advances in prokaryotic synthetic networks and possess an impressive range of functionalities that will some day enable the engineering of sophisticated inter- and intra-cellular functions to become a reality. At a relatively simple level, the modular linking of transcriptional components has enabled the creation of genetic networks that are strongly analogous to the architectural design and functionality of electronic circuits. Thus, by combining components in different serial or parallel configurations it is possible to produce networks that follow strict logic in integrating multiple independent signals (logic gates and transcriptional cascades) or which temporally modify input signals (time-delay circuits). Progressing in terms of sophistication, synthetic transcriptional networks have also been constructed which emulate naturally occurring genetic properties, such as bistability or dynamic instability. Toggle switches which possess ``memory'' so as to remember transient administered inputs, hysteric switches which are resistant to stochastic fluctuations in inputs, and oscillatory networks which produce regularly timed expression outputs, are all examples of networks that have been constructed using such properties. Initial steps have also been made in designing the above networks to respond not only to exogenous signals, but also endogenous signals that may be associated with aberrant cellular function or physiology thereby providing a means for tightly controlled gene therapy applications. Moving beyond pure transcriptional control, synthetic networks have also been created which utilize phenomena, such as post-transcriptional silencing, translational control, or inter-cellular signaling to produce novel network-based control both within and between cells. It is envisaged in the not-too-distant future that these networks will provide the basis for highly sophisticated genetic manipulations in biopharmaceutical manufacturing, gene therapy and tissue engineering applications. | ||
| ref11 | electronic | Bacteria can be turned into living computers - Telegraph - on article in J Biol Eng | synthetic biology | http://www.telegraph.co.uk/earth/main.jhtml?view=DETAILS&grid=&xml=/earth/2008/05/20/scibacteria120.xml | Bacteria have been turned into ``living computers'' and used to solve a mathematical problem. The feat by an American team shows that computing using living cells is feasible, opening the door to a number of applications including data storage. The research is part of a general effort in ``synthetic biology'' to improve on four billion years of evolution and turn bacteria into living machines to do our bidding. The results, published in the Journal of Biological Engineering, are reported by Karmella Haynes and colleagues from the biology and the mathematics departments of Davidson College, North Carolina and Missouri Western State University, Missouri. They added genes to an innocuous form of the gut bacterium Escherichia coli, a workhorse of genetics research, creating bacterial computers able to solve a classic mathematical puzzle, known as the Burnt Pancake Problem. | ||||||||||
| ref12 | electronic | The crucial role of CS in systems and synthetic biology | computer science | http://portal.acm.org/citation.cfm?id=1342332 | |||||||||||
| Bashor2008a | article | Bashor, Caleb ; Helman, Noah ; Yan, Shude ; Lim, Wendell | Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics | Science | 2008 | Mar | 14 | 319 | 5869 | 1539--1543 | Biotech | 10.1126/science.1151153 | http://www.sciencemag.org/cgi/content/abstract/319/5869/1539 | ||
| Linshiz2008 | article | Linshiz, Gregory ; ben Yehezkel, Tuval ; Kaplan, Shai ; Gronau, Ilan ; Ravid, Sivan ; Adar, Rivka ; Shapiro, Ehud | Recursive construction of perfect DNA molecules from imperfect oligonucleotides | Mol Syst Biol | 2008 | May | 06 | 4 | DNA synthesis | 10.1038/msb.2008.26 | http://www.nature.com/msb/journal/v4/n1/full/msb200826.html | ||||
| ref15 | electronic | Main Page - 2008.igem.org | genome | http://2008.igem.org/Main_Page | iGEM is the premiere undergraduate Synthetic Biology competition. Student teams are given a kit of biological parts at the beginning of the summer. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells. During the weekend of November 8-9, they present their work at the iGEM Competition Jamboree at MIT and have a chance to win awards. They add their new parts to the Registry of Standard Biological Parts for the students in the next year's competition. | ||||||||||
| ref16 | electronic | PLoS Computational Biology: Biosynthetic Potentials of Metabolites and Their Hierarchical Organization | to read | http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000049 | |||||||||||
| ref17 | electronic | PLoS Computational Biology: The Evolution of Robust Development and Homeostasis in Artificial Organisms | synthetic biology | http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000030 | |||||||||||
| Serrano2007 | article | Serrano, Luis | Synthetic biology: promises and challenges | Mol Syst Biol | 2007 | Dec | 18 | 3 | synthetic biology | 10.1038/msb4100202 | http://www.nature.com/msb/journal/v3/n1/full/msb4100202.html | ||||
| Doktycz2007 | article | Doktycz, Mitchel ; Simpson, Michael | Nano-enabled synthetic biology | Mol Syst Biol | 2007 | Jul | 10 | 3 | synthetic biology | 10.1038/msb4100165 | http://www.nature.com/msb/journal/v3/n1/full/msb4100165.html | ||||
| Bashor2008b | article | Bashor, Caleb ; Helman, Noah ; Yan, Shude ; Lim, Wendell | Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics | Science | 2008 | Mar | 14 | 319 | 5869 | 1539--1543 | synthetic biology | 10.1126/science.1151153 | http://www.sciencemag.org/cgi/content/full/319/5869/1539 | ||
| Gibson2008 | article | Gibson, Daniel G. ; Benders, Gwynedd A. ; Andrews-Pfannkoch, Cynthia ; Denisova, Evgeniya A. ; Baden-Tillson, Holly ; Zaveri, Jayshree ; Stockwell, Timothy B. ; Brownley, Anushka ; Thomas, David W. ; Algire, Mikkel A. ; Merryman, Chuck ; Young, Lei ; Noskov, Vladimir N. ; Glass, John I. ; Venter, J. Craig ; Hutchison, Clyde A. III ; Smith, Hamilton O. | Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome | Science (New York, N.Y.) | 2008 | Jan | 24 | 319 | 5867 | 1151721--1220 | Venter | 10.1126/science.1151721 | 1095-9203 | http://dx.doi.org/10.1126/science.1151721 | |
| ref22 | electronic | Synthetic Gene Circuits: Design with Directed Evolution - Annual Review of Biophysics and Biomolecular Structure, 36(1):1 - Abstract | review | http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.biophys.36.040306.132600 | |||||||||||
| ref23 | article | Synthetic Gene Circuits: Design with Directed Evolution | Annual Review of Biophysics and Biomolecular Structure | 2007 | xx | xx | 36 | 1 | 1 | BioBrick Characterisation | 10.1146/annurev.biophys.36.040306.132600 | 10568700 | http://dx.doi.org/10.1146/annurev.biophys.36.040306.132600 | ||
| Sauro2008 | article | Sauro, Herbert | Modularity defined | Mol Syst Biol | 2008 | Feb | 12 | 4 | systems biology | 10.1038/msb.2008.3 | http://www.nature.com/msb/journal/v4/n1/full/msb20083.html | commentary on Del Vecchio et al (2008). | |||
| ref25 | electronic | From the cells up | Science | The Guardian | synthetic biology | http://www.guardian.co.uk/science/2005/mar/10/science.research | |||||||||||
| ref26 | electronic | Laying the foundations for a bio-economy 2008 | carlson | http://www.springerlink.com/content/n211746672413507/fulltext.pdf | |||||||||||
| ref27 | electronic | hackwriters.com - 21st Century Identity - Memory and Personality - Kim Pfiefer | emergent evolution | http://www.hackwriters.com/identity21.htm | The coming horrors of body-parts manufacture and cloning. | ||||||||||
| Benders2008 | article | Benders, Gwynedd ; Hamilton, And | Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome | Science | 2008 | Jan | 24 | 1151721 | synthetic biology | 10.1126/science.1151721 | http://www.sciencemag.org/cgi/content/abstract/319/5867/1215?sa_campaign=Email/toc/29-February-2008/10.1126/science.1151721 | We have synthesized a 582,970 bp Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted ``watermarks'' at intergenic sites known to tolerate transposon insertions. Overlapping ``cassettes'' of 5 to 7 kb, assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate assemblies of approximately 24 kb, 72 kb (``1/8 genome''), and 144 kb (``1/4 genome''), which were all cloned as bacterial artificial chromosomes (BACs) in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination (TAR) cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. | |||
| ref29 | electronic | Genome stitched together by hand : Nature News - on article in Science | synthetic biology | http://www.nature.com/news/2008/080124/full/news.2008.522.html | Scientists have succeeded in stitching together an entire bacterial genome, creating in the lab the full set of instructions needed to make a living thing. The stage is now set for the creation of the first artificial organism — and it could be achieved within the year. The genome for the pathogenic bacterium Mycoplasma genitalium was made in the laboratory by Hamilton Smith and his colleagues at the J. Craig Venter Institute in Rockville, Maryland. The genome has 582,970 of the fundamental building blocks of DNA, called nucleotide bases, making it more than a factor of ten longer than the previous-longest stretch of genetic material created by chemical means. | ||||||||||
| ref30 | electronic | ETC Group - | synthetic biology | http://www.etcgroup.org/en/ | Synthetic Biology Cartoons | ||||||||||
| Pennisi2008 | article | Pennisi, Elizabeth | Scientists Synthesize a Genome From Scratch - on article in Science | ScienceNOW | 2008 | Jan | 24 | 2008 | 124 | 3 | synthetic biology | http://sciencenow.sciencemag.org/cgi/content/full/2008/124/3 | Researchers have rebuilt an entire genome from scratch, they report online today in Science. Although the team has yet to demonstrate that this DNA can substitute for the real thing, the work paves the way for customized bacteria that could efficiently produce drugs, biofuels, and other molecules useful to humankind. Ever since his group decoded the genome of Mycoplasma genitalium, a parasitic bacterium that lives in the human urogenital tract, sequencing maverick J. Craig Venter has wanted to remake the bug's genome in the lab. At just under 600,000 bases, M. genitalium sports the smallest known genome for a free-living organism, and Venter hoped that an artificial genome could be modified to turn the bacterium into a living chemical-manufacturing plant. | ||
| ref32 | electronic | Scientists Take New Step Toward Man-Made Life - on article in Science | synthetic biology | http://www.nytimes.com/2008/01/24/science/24cnd-genome.html | Taking a significant step toward the creation of man-made forms of life, researchers reported Thursday that they had manufactured the entire genome of a bacterium by painstakingly stitching together its chemical components. While scientists had previously synthesized the complete DNA of viruses, this is the first time it has been done for bacteria, which are much more complex. The genome is more than 10 times as long as the longest piece of DNA ever previously synthesized. | ||||||||||
| Sidney2007a | article | Sidney, Robert ; Cox, ; Surette, Michael ; Elowitz, Michael | Programming gene expression with combinatorial promoters | Mol Syst Biol | 2007 | Nov | 13 | 3 | Promoter | 10.1038/msb4100187 | http://www.nature.com/msb/journal/v3/n1/full/msb4100187.html | ||||
| ref34 | article | Systems interface biology | Journal of The Royal Society Interface | 2006 | xx | xx | 3 | 10 | 603 | stochastic | 10.1098/rsif.2006.0143 | http://dx.doi.org/10.1098/rsif.2006.0143 | |||
| Cox2007 | article | Cox, Robert Sidney ; Surette, Michael ; Elowitz, Michael | Programming gene expression with combinatorial promoters | Mol Syst Biol | 2007 | Nov | 13 | 3 | synthetic biology | 10.1038/msb4100187 | http://www.nature.com/msb/journal/v3/n1/full/msb4100187.html | ||||
| ref36 | article | Programming and engineering biological networks | Current Opinion in Structural Biology | 2006 | xx | xx | 16 | 4 | 551 | synthetic biology | 10.1016/j.sbi.2006.06.011 | http://dx.doi.org/10.1016/j.sbi.2006.06.011 | |||
| ref37 | electronic | Registry of Standard Biological Parts | registry | http://parts.mit.edu/registry/index.php/Main_Page | |||||||||||
| ref38 | electronic | BioMed Central | Abstract | 1752-0509-1-50 | Noise-induced switches in network systems of the genetic toggle switch | noise | http://www.biomedcentral.com/1752-0509/1/50 | |||||||||||
| Sidney2007b | article | Sidney, Robert ; Cox, ; Surette, Michael ; Elowitz, Michael | Programming gene expression with combinatorial promoters | Mol Syst Biol | 2007 | Nov | 13 | 3 | synthetic biology | 10.1038/msb4100187 | http://www.nature.com/msb/journal/v3/n1/full/msb4100187.html | ||||
| ref40 | article | Noise and kinetics of LuxR positive feedback loops | Biochemical and Biophysical Research Communications | 2007 | xx | xx | 363 | 3 | 667 | synthetic biology | 10.1016/j.bbrc.2007.09.057 | http://dx.doi.org/10.1016/j.bbrc.2007.09.057 | |||
| ref41 | article | Design and implementation of three incoherent feed-forward motif based biological concentration sensors | Systems and Synthetic Biology | 2007 | xx | xx | synthetic biology | 10.1007/s11693-007-9008-6 | 18725325 | http://dx.doi.org/10.1007/s11693-007-9008-6 | |||||
| ref42 | electronic | BBC NEWS | Science/Nature | Creating life in the laboratory | synthetic biology | http://news.bbc.co.uk/2/hi/science/nature/7041353.stm | The race to create life version 2.0 is under way. The J Craig Venter Institute scientists are aiming to craft a ``minimal genome''- the smallest group of genes an organism needs to survive and function - and insert it into an empty cell. This stripped-down genome has been established with the help of a simple bacterium, Mycoplasma genitalium, by knocking out its genes, one by one, until only the genetic material vital for survival was found. | ||||||||||
| ref43 | article | Expanding the metabolic engineering toolbox: more options to engineer cells | Trends in Biotechnology | 2007 | xx | xx | 25 | 3 | 132 | BioBrick Characterisation | 10.1016/j.tibtech.2007.01.003 | http://dx.doi.org/10.1016/j.tibtech.2007.01.003 | |||
| Wu2007 | article | Wu, Gang ; Dress, Laura ; Freeland, Stephen | Optimal encoding rules for synthetic genes: the need for a community effort | Mol Syst Biol | 2007 | Sep | 18 | 3 | synthetic biology | 10.1038/msb4100176 | http://www.nature.com/msb/journal/v3/n1/full/msb4100176.html | ||||
| Murphy2007a | article | Murphy, Kevin ; Bal{\'a}zsi, G{\'a}bor ; Collins, James | Combinatorial promoter design for engineering noisy gene expression. | Proceedings of the National Academy of Sciences of the United States of America | 2007 | Jul | 31 | 104 | 31 | 12726--12731 | synthetic biology | 10.1073/pnas.0608451104 | http://www.pnas.org/cgi/content/abstract/0608451104v1?maxtoshow=&HITS=1&hits=1&RESULTFORMAT=&andorexacttitle=and&titleabstract=synthetic+biology&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&usestrictdates=yes&resourcetype=HWCIT&ct | ||
| Luisi2007 | article | Luisi, Pier | Chemical Aspects of Synthetic Biology | Chemistry \& Biodiversity | 2007 | xx | xx | 4 | 4 | 603--621 | synthetic biology | 10.1002/cbdv.200790053 | http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17443874&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus | ||
| ref47 | article | Synthetic biology: lessons from the history of synthetic organic chemistry | Nature Chemical Biology | 2007 | xx | xx | 3 | 9 | 521--521 | synthetic biology | 10.1038/nchembio0907-521 | http://dx.doi.org/10.1038/nchembio0907-521 | |||
| ref48 | electronic | Prather Group - Home Page | Lab | http://web.mit.edu/prathergroup/index.html | Our research is centered on the design and assembly of recombinant microorganisms for the production of small molecules. More simply, we are harnessing the synthetic power of biology to build microbial chemical factories. Current efforts include the development of tools and methodologies for novel biosynthetic pathway design and the investigation of gene dosage effects on the physiology and productivity of engineered microbes. Our research combines the traditions of metabolic engineering with the practices of biocatalysis to expand and optimize the biosynthetic capacity of microbial systems. A particular focus is the elucidation of design principles for the production of unnatural organic compounds within the framework of the nascent field of synthetic biology. Major Research Areas | ||||||||||
| Pedraza2005a | article | Pedraza, Juan ; van Oudenaarden, Alexander | Noise propagation in gene networks. | Science (New York, N.Y.) | 2005 | Mar | 25 | 307 | 5717 | 1965--1969 | synthetic biology | 10.1126/science.1109090 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15790857&query_hl=12 | ||
| Hooshangi2005a | article | Hooshangi, Sara ; Thiberge, Stephan ; Weiss, Ron | Ultrasensitivity and noise propagation in a synthetic transcriptional cascade | Proceedings of the National Academy of Sciences | 2005 | Mar | 08 | 102 | 10 | 3581--3586 | inverter composition | 10.1073/pnas.0408507102 | http://dx.doi.org/10.1073/pnas.0408507102 | ||
| ref51 | electronic | Cell -- Deans et al. | synthetic biology | http://www.cell.com/content/article/abstract?uid=PIIS0092867407006848 | |||||||||||
| Murphy2007b | article | Murphy, Kevin ; Balazsi, Gabor ; Collins, James | Combinatorial promoter design for engineering noisy gene expression | Proceedings of the National Academy of Sciences | 2007 | Jul | 31 | 104 | 31 | 12726--12731 | synthetic biology | 10.1073/pnas.0608451104 | http://www.pnas.org/cgi/content/abstract/0608451104v1?maxtoshow=&HITS=1&hits=1&RESULTFORMAT=&andorexacttitle=and&titleabstract=synthetic+biology&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&usestrictdates=yes&resourcetype=HWCIT&ct | ||
| Grilly2007 | article | Grilly, Chris ; Stricker, Jesse ; Pang, Wyming ; Bennett, Matthew ; Hasty, Jeff | A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae | Mol Syst Biol | 2007 | Jul | 31 | 3 | synthetic biology | 10.1038/msb4100168 | http://www.nature.com/msb/journal/v3/n1/full/msb4100168.html | ||||
| Waldminghaus2007 | article | Waldminghaus, Torsten ; Gaubig, Lena ; Narberhaus, Franz | Genome-wide bioinformatic prediction and experimental evaluation of potential RNA thermometers. | Mol Genet Genomics | 2007 | Jul | 24 | synthetic biology | 10.1007/s00438-007-0272-7 | http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17647020&itool=pubmed_DocSum | |||||
| ref55 | article | Toward an artificial cell based on gene expression in vesicles. | Physical Biology | 2005 | xx | xx | 2 | 3 | 1--1 | synthetic biology | 10.1088/1478-3975/2/3/p01 | http://www.ncbi.nlm.nih.gov/pubmed/16224117?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus | |||
| Rinaudo2007a | article | Rinaudo, Keller ; Bleris, Leonidas ; Maddamsetti, Rohan ; Subramanian, Sairam ; Weiss, Ron ; Benenson, Yaakov | A universal RNAi-based logic evaluator that operates in mammalian cells | Nat Biotech | 2007 | Jul | xx | 25 | 7 | 795--801 | synthetic biology | 10.1038/nbt1307 | http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt1307.html | ||
| Szczepek2007 | article | Szczepek, Michal ; Brondani, Vincent ; B{\"u}chel, Janine ; Serrano, Luis ; Segal, David ; Cathomen, Toni | Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. | Nature biotechnology | 2007 | Jul | xx | 25 | 7 | 786--793 | zinc-finger nuclease | 10.1038/nbt1317 | http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1317.html | ||
| Miller2007 | article | Miller, Jeffrey ; Holmes, Michael ; Wang, Jianbin ; Guschin, Dmitry ; Lee, Ya-Li ; Rupniewski, Igor ; Beausejour, Christian ; Waite, Adam ; Wang, Nathaniel ; Kim, Kenneth ; Gregory, Philip ; Pabo, Carl ; Rebar, Edward | An improved zinc-finger nuclease architecture for highly specific genome editing. | Nature biotechnology | 2007 | Jul | xx | 25 | 7 | 778--785 | Protein engineering | 10.1038/nbt1319 | http://dx.doi.org/10.1038/nbt1319 | ||
| Wang2007 | article | Wang, Kaihang ; Neumann, Heinz ; Peak-Chew, Sew ; Chin, Jason | Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion. | Nature biotechnology | 2007 | Jul | xx | 25 | 7 | 770--777 | orthogonal | 10.1038/nbt1314 | http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1314.html | ||
| Walter2007 | article | Walter, Jessica ; Greenfield, Derek ; Bustamante, Carlos ; Liphardt, Jan | Light-powering Escherichia coli with proteorhodopsin | Proceedings of the National Academy of Sciences | 2007 | Feb | 13 | 104 | 7 | 2408--2412 | proteorhodopsin | 10.1073/pnas.0611035104 | http://dx.doi.org/10.1073/pnas.0611035104 | ||
| Drubin2007a | article | Drubin, David ; Way, Jeffrey ; Silver, Pamela | Designing biological systems. | Genes \& development | 2007 | Feb | 01 | 21 | 3 | 242--254 | be theory | 10.1101/gad.1507207 | http://www.genesdev.org/cgi/content/full/21/3/242 | ||
| Andrianantoandro2006a | article | Andrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, Ron | Synthetic biology: new engineering rules for an emerging discipline. | Molecular systems biology | 2006 | xx | xx | 2 | 2006--0028 | synthetic biology | 10.1038/msb4100073 | http://www.nature.com/msb/journal/v2/n1/full/msb4100073.html | |||
| Ball2007a | article | Ball, Philip | Synthetic biology: Designs for life | Nature | 2007 | Jul | 05 | 448 | 7149 | 32--33 | synthetic biology | 10.1038/448032a | http://www.nature.com/nature/journal/v448/n7149/full/448032a.html | ||
| Ball2007b | article | Ball, Philip | Synthetic biology: Designs for life - on article in Science | Nature | 2007 | Jul | 05 | 448 | 7149 | 32--33 | synthetic biology | 10.1038/448032a | http://www.nature.com/nature/journal/v448/n7149/full/448032a.html | The genome of one bacterium has been successfully replaced with that of a different bacterium, transforming one species into another. This development is a harbinger of whole-genome engineering for practical ends. | |
| Yeh2007a | article | Yeh, Brian ; Rutigliano, Robert ; Deb, Anrica ; Bar-Sagi, Dafna ; Lim, Wendell | Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors | Nature | 2007 | May | 31 | 447 | 7144 | 596--600 | gtpase | 10.1038/nature05851 | http://www.nature.com/nature/journal/vaop/ncurrent/abs/nature05851.html | ||
| Lartigue2007a | article | Lartigue, Carole ; Glass, John ; Alperovich, Nina ; Pieper, Rembert ; Parmar, Prashanth ; Hutchison, III Clyde ; Smith, Hamilton ; Venter, J. | Genome Transplantation in Bacteria: Changing One Species to Another | Science | 2007 | Jun | 28 | 1144622--1144622 | synthetic biology | 10.1126/science.1144622 | http://www.sciencemag.org/cgi/content/abstract/1144622 | My comments: Venter and colleagues describe a method for replacing a chromosome in one bacteria by another from another bacteria (the two bacteria being distinct species, although {\textasciitilde}95\% identical at the genome level in this case). One of the challenges was in the extraction of intact, protein-free chromosomes from cells. The actual transfer then relies on polyethylene glycol (PEG), known to promote fusion of eukaryotic cells, but the actual transplantation mechanism is not understood. The authors hypothesize that two chromosome-free cells might fuse around a naked chromosome, with low frequency (but the resulting cells are selected using an antibiotics resistance gene). Nonetheless, this is clearly an important step forward for synthetic biology (you can imagine that entirely synthesized chromosomes will be inserted into empty host cells using this type of approaches). | |||
| ref67 | electronic | Scientists Report DNA Transplant - washingtonpost.com - on article in Science | synthetic biology | http://www.washingtonpost.com/wp-dyn/content/article/2007/06/28/AR2007062802046.html | Scientists said yesterday that they had transplanted a microbe's entire, tangled mass of DNA into a closely related organism, a delicate operation that cleanly transformed the recipient from one species into the other. After the operations, the ``patients'' -- single-celled organisms resembling bacteria -- dutifully obeyed their new genomes and by every measure exhibited the biological personas of the donors. | ||||||||||
| Pennisi2007 | article | Pennisi, Elizabeth | GENETICS: Replacement Genome Gives Microbe New Identity | Science | 2007 | Jun | 29 | 316 | 5833 | 1827--1827 | synthetic biology | 10.1126/science.316.5833.1827a | http://www.sciencemag.org/cgi/content/full/316/5833/1827a | For decades, molecular biologists have genetically modified microbes and other kinds of cells by adding short DNA sequences, whole genes, and even large pieces of chromosomes. Now, in a feat reported in a paper published online by Science this week (www.sciencemag.org/cgi/content/abstract/1144622), one group has induced a bacterium to take up an entire 1.08-million-base genome in one gulp. In doing so, microbiologist John Glass and his colleagues at the J. Craig Venter Institute in Rockville, Maryland, have transformed one bacterial species into another. | |
| Lartigue2007b | article | Lartigue, Carole ; Glass, John ; Alperovich, Nina ; Pieper, Rembert ; Parmar, Prashanth ; Hutchison, III Clyde ; Smith, Hamilton ; Venter, J. | Genome Transplantation in Bacteria: Changing One Species to Another | Science | 2007 | Jun | 28 | 1144622--1144622 | synthetic biology | 10.1126/science.1144622 | http://www.sciencemag.org/cgi/content/abstract/1144622 | As a step toward propagation of synthetic genomes, we completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA. Intact genomic DNA from Mycoplasma mycoides large colony (LC), virtually free of protein, was transplanted into Mycoplasma capricolum cells by polyethylene glycol-mediated transformation. Cells selected for tetracycline resistance, carried by the M. mycoides LC chromosome, contain the complete donor genome and are free of detectable recipient genomic sequences. These cells that result from genome transplantation are phenotypically identical to the M. mycoides LC donor strain as judged by several criteria. | |||
| ref70 | electronic | Genome transplant makes species switch - on article in Science | synthetic biology | http://www.nature.com/news/2007/070625/full/070625-9.html | By transplanting their genomes, US scientists have converted one species into another. John Glass and his co-workers at the J. Craig Venter Institute in Rockville, Maryland, have taken DNA from a bacterium called Mycoplasma mycoides and inserted it into cells of the closely related species Mycoplasma capricolum. They find that the recipient cells with the new genome behave like those of the donor species, making protein molecules characteristic of the donor. It's like re-booting a cell with a new operating system, says Glass. | ||||||||||
| ref71 | article | Meanings of 'life' | Nature | 2007 | Jun | 28 | 447 | 7148 | 1031--1032 | synthetic biology | 10.1038/4471031b | http://www.nature.com/nature/journal/v447/n7148/full/4471031b.html | |||
| Kaiser2007 | article | Kaiser, Jocelyn | SYNTHETIC BIOLOGY: Attempt to Patent Artificial Organism Draws a Protest | Science | 2007 | Jun | 15 | 316 | 5831 | 1557--1557 | synthetic biology | 10.1126/science.316.5831.1557 | http://www.sciencemag.org/cgi/content/full/316/5831/1557 | An activist group's concern about maverick genome sequencer J. Craig Venter's intention to patent an entirely synthetic free-living organism has thrown a spotlight on the emerging intellectual-property landscape in this hot new field. The protesters claim that Venter wants his company to become the Microsoft of synthetic biology, dominating the industry. | |
| ref73 | electronic | Man-made microbe 'to create endless biofuel' | Uk News | News | Telegraph | synthetic biology | http://www.telegraph.co.uk/news/main.jhtml?xml=/news/2007/06/08/nbiofuel108.xml | A scientist is poised to create the world's first man-made species, a synthetic microbe that could lead to an endless supply of biofuel. Craig Venter, an American who cracked the human genome in 2000, has applied for a patent at more than 100 national offices to make a bacterium from laboratory-made DNA. It is part of an effort to create designer bugs to manufacture hydrogen and biofuels, as well as absorb carbon dioxide and other harmful greenhouse gases. | ||||||||||
| Rinaudo2007b | article | Rinaudo, Keller ; Bleris, Leonidas ; Maddamsetti, Rohan ; Subramanian, Sairam ; Weiss, Ron ; Benenson, Yaakov | A universal RNAi-based logic evaluator that operates in mammalian cells | Nat Biotech | 2007 | May | 21 | advanced online publication | synthetic biology | 10.1038/nbt1307 | http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt1307.html | ||||
| Dueber2007 | article | Dueber, John ; Mirsky, Ethan ; Lim, Wendell | Engineering synthetic signaling proteins with ultrasensitive input/output control | Nat Biotech | 2007 | Jun | xx | 25 | 6 | 660--662 | synthetic biology | 10.1038/nbt1308 | http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1308.html | ||
| ref76 | electronic | ETC Group - Publications - Patenting Pandora’s Bug: Goodbye, Dolly...Hello, Synthia! J. Craig Venter Institute Seeks Monopoly Patents on the World’s First-Ever Human-Made Life Form | synthetic biology | http://www.etcgroup.org/en/materials/publications.html?pub_id=631 | The Venter Institute - named for its founder and CEO, J. Craig Venter, the scientist who led the private sector race to map the Human Genome - is applying for worldwide patents on what they refer to as ``Mycoplasma laboratorium.'' | ||||||||||
| ref77 | electronic | Second Life, or Not? -- Kaiser 2007 (607): 3 -- ScienceNOW | synthetic biology | http://sciencenow.sciencemag.org/cgi/content/full/2007/607/3 | An activist group is raising a ruckus about what it says may be the first effort to patent an entirely synthetic free-living organism. It says the patent application, filed by maverick genome sequencer Craig Venter's institute on an idea that has likely not yet been achieved, would tie up a new technology and could aid bioterrorists. But others say there's nothing new or surprising about the patenting effort. The work involves a simple bacterium called Mycoplasma genitalium that Venter's eponymous institute in Rockville, Maryland, has been tinkering with for years. An early goal was to determine the minimum number of genes for life, and in 1999, scientists there published a rough tally. Now, they want to synthesize this ``minimal genome'' from scratch, get it working inside a cell, then add genes that would enable the bug to crank out hydrogen or ethanol to produce cheap energy. | ||||||||||
| Andrianantoandro2006b | article | Andrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, Ron | Synthetic biology: new engineering rules for an emerging discipline. | Molecular systems biology | 2006 | xx | xx | 2 | 2006--0028 | synthetic biology | 10.1038/msb4100073 | http://www.nature.com/msb/journal/v2/n1/full/msb4100073.html | |||
| Yeh2007b | article | Yeh, Brian ; Rutigliano, Robert ; Deb, Anrica ; Bar-Sagi, Dafna ; Lim, Wendell | Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors | Nature | 2007 | May | 31 | 447 | 7144 | 596--600 | synthetic biology | 10.1038/nature05851 | http://www.nature.com/nature/journal/vaop/ncurrent/abs/nature05851.html | ||
| ref80 | electronic | Scientists Push the Boundaries of Human Life - Newsweek: International Editions - MSNBC.com | synthetic biology | http://www.msnbc.msn.com/id/18882828/site/newsweek/page/0/ | |||||||||||
| ref81 | electronic | Synthetic biology--putting engineering into biology -- Heinemann and Panke 22 (22): 2790 -- Bioinformatics | synthetic biology | http://bioinformatics.oxfordjournals.org/cgi/content/abstract/22/22/2790 | |||||||||||
| ref82 | electronic | Main Page - IGEM | synthetic biology | http://parts2.mit.edu/wiki/index.php/Main_Page | The international Genetically Engineered Machine competition iGEM is an international arena where student teams compete to design and assemble engineered machines using advanced genetic components and technologies. Learn more. | ||||||||||
| ref83 | electronic | SynBERC - Synthetic Biology Engineering Research Center | synthetic biology | http://www.synberc.org/index.html | Consortium of organizations to develop synthetic biology applocations, tools and ethics. Promoted by Drew Endy and George Church. also linked to the IGEM program. | ||||||||||
| ref84 | article | The Generation of New Protein Functions by the Combination of Domains | Structure | 2007 | xx | xx | 15 | 1 | 85--85 | synthetic biology | 10.1016/j.str.2006.11.009 | http://dx.doi.org/10.1016/j.str.2006.11.009 | |||
| Chen2007 | article | Chen, Chun-Hong ; Huang, Haixia ; Ward, Catherine ; Su, Jessica ; Schaeffer, Lorian ; Guo, Ming ; Hay, Bruce | A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. | Science (New York, N.Y.) | 2007 | Apr | 27 | 316 | 5824 | 597--600 | synthetic biology | 10.1126/science. 1138595 | http://www.sciencemag.org/cgi/content/abstract/1138595 | ||
| ref86 | article | A synthetic biology challenge: making cells compute | Molecular BioSystems | 2007 | xx | xx | synthetic biology | 10.1039/b618473c | http://dx.doi.org/10.1039/b618473c | ||||||
| ref87 | article | Multiple High-Throughput Analyses Monitor the Response of E. coli to Perturbations | Science | 2007 | xx | xx | 316 | 5824 | 593--593 | Lab techniques | 10.1126/science.1132067 | http://www.sciencemag.org/cgi/content/abstract/1132067v1?etoc | |||
| ref88 | electronic | In situ DNA synthesis on glass substrate for microarray fabrication using self-focusing acoustic transducer | synthetic biology | http://ieeexplore.ieee.org/search/srchabstract.jsp?arnumber=1613915&isnumber=33881&punumber=8856&k2dockey=1613915@ieeejrns&query=(+eun+sok+kim%3Cin%3Eau)&pos=3 | A proof of concept of using SFATs (self-focusing acoustic transducers) to print DNA oligos. | ||||||||||
| Chan2005 | article | Chan, Leon ; Kosuri, Sriram ; Endy, Drew | Refactoring bacteriophage T7. | Molecular systems biology | 2005 | xx | xx | 1 | 2005--0018 | refactoring | 10.1038/msb4100025 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16729053&query_hl=5&itool=pubmed_docsum | |||
| Zhang2007 | article | Zhang, Feng ; Wang, Li-Ping ; Brauner, Martin ; Liewald, Jana ; Kay, Kenneth ; Watzke, Natalie ; Wood, Phillip ; Bamberg, Ernst ; Nagel, Georg ; Gottschalk, Alexander ; Deisseroth, Karl | Multimodal fast optical interrogation of neural circuitry | Nature | 2007 | Apr | 05 | 446 | 7136 | 633--639 | Neurobiology | 10.1038/nature05744 | http://www.nature.com/nature/journal/v446/n7136/abs/nature05744.html | ||
| ref91 | electronic | Applied Biodynamics Laboratory, Boston U. | Lab | http://www.bu.edu/abl/ | Our lab is focused on developing and using nonlinear dynamics approaches to study, mimic and improve the function of biological systems. We are currently working in three areas:SB andsynrhetic biology | ||||||||||
| Andrianantoandro2006c | article | Andrianantoandro, Ernesto ; Basu, Subhayu ; Karig, David ; Weiss, Ron | Synthetic biology: new engineering rules for an emerging discipline. | Molecular systems biology [electronic resource]. | 2006 | xx | xx | 2 | 2006--0028 | systems biology | 10.1038/msb4100073 | http://www.nature.com/msb/journal/v2/n1/full/msb4100073.html | |||
| Heinemann2006 | article | Heinemann, Matthias ; Panke, Sven | Synthetic biology--putting engineering into biology. | Bioinformatics (Oxford, England) | 2006 | Nov | 15 | 22 | 22 | 2790--2799 | systems biology | 10.1093/bioinformatics/btl469 | http://dx.doi.org/10.1093/bioinformatics/btl469 | ||
| Drubin2007b | article | Drubin, David ; Way, Jeffrey ; Silver, Pamela | Designing biological systems. | Genes \& development | 2007 | Feb | 01 | 21 | 3 | 242--254 | systems biology | 10.1101/gad.1507207 | http://www.genesdev.org/cgi/content/full/21/3/242 | ||
| Sismour2005 | article | Sismour, A. ; Benner, Steven | Synthetic biology. | Expert opinion on biological therapy | 2005 | Nov | xx | 5 | 11 | 1409--1414 | systems biology | 10.1517/14712598.5.11.1409 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16255644&query_hl=1&itool=pubmed_DocSum | ||
| ref96 | electronic | SpringerLink - Journal Article | synthetic biology | http://www.springerlink.com/content/k7377586j4305247/ | |||||||||||
| Yokobayashi2002a | article | Yokobayashi, Yohei ; Weiss, Ron ; Arnold, Frances | From the Cover: Directed evolution of a genetic circuit | Proceedings of the National Academy of Sciences | 2002 | Dec | 24 | 99 | 26 | 16587--16591 | synthetic biology | 10.1073/pnas.252535999 | http://www.pnas.org/cgi/content/abstract/99/26/16587?etoc | ||
| ref98 | article | Genetic parts to program bacteria | Current Opinion in Biotechnology | 2006 | xx | xx | 17 | 5 | 548--548 | synthetic biology | 10.1016/j.copbio.2006.09.001 | http://dx.doi.org/10.1016/j.copbio.2006.09.001 | |||
| ref99 | article | The Generation of New Protein Functions by the Combination of Domains | Structure | 2007 | xx | xx | 15 | 1 | 85--85 | structures | 10.1016/j.str.2006.11.009 | http://dx.doi.org/10.1016/j.str.2006.11.009 | |||
| Sprinzak2005a | article | Sprinzak, David ; Elowitz, Michael | Reconstruction of genetic circuits | Nature | 2005 | Nov | 24 | 438 | 7067 | 443--448 | synthetic biology | 10.1038/nature04335 | http://www.nature.com/nature/journal/v438/n7067/full/nature04335.html | ||
| Hasty2001 | book | Hasty, Jeff ; Isaacs, Farren ; Dolnik, Milos ; McMillen, David ; Collins, J. J. | Designer Gene Networks: Towards Fundamental Cellular Control | 2001 | Mar | 13 | genetic network | http://arxiv.org/abs/physics/0103034 | |||||||
| Fox2007 | article | Fox, Richard ; Davis, S. ; Mundorff, Emily ; Newman, Lisa ; Gavrilovic, Vesna ; Ma, Steven ; Chung, Loleta ; Ching, Charlene ; Tam, Sarena ; Muley, Sheela ; Grate, John ; Gruber, John ; Whitman, John ; Sheldon, Roger ; Huisman, Gjalt | Improving catalytic function by ProSAR-driven enzyme evolution | Nat Biotech | 2007 | Feb | 18 | advanced online publication | directed evolution | 10.1038/nbt1286 | http://www.nature.com/nbt/journal/vaop/ncurrent/abs/nbt1286.html | ||||
| ref103 | article | Synthetic biology projects in vitro | Genome Research | 2006 | xx | xx | 17 | 1 | 1--1 | Cell-Free System | 10.1101/gr.5776007 | http://www.genome.org/cgi/content/abstract/gr.5776007v1?papetoc | |||
| ref104 | article | Genome Biology | Full text | Fast, cheap and somewhat in control | Genome Biology | 2006 | xx | xx | 7 | 8 | 114--114 | synthetic biology | 10.1186/gb-2006-7-8-114 | http://dx.doi.org/10.1186/gb-2006-7-8-114 | |||
| Thattai2004 | article | Thattai, Mukund ; Van Oudenaarden, Alexander | Stochastic Gene Expression in Fluctuating Environments | Genetics | 2004 | May | 01 | 167 | 1 | 523--530 | gene expression | 10.1534/genetics.167.1.523 | http://www.genetics.org/cgi/content/abstract/167/1/523 | ||
| Li2007 | article | Li, Mamie ; Elledge, Stephen | Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC | Nat Meth | 2007 | Feb | 11 | advanced online publication | method | 10.1038/nmeth1010 | http://www.nature.com/nmeth/journal/vaop/ncurrent/abs/nmeth1010.html | ||||
| ref107 | electronic | ETC Group - Publications - Extreme Genetic Engineering: An Introduction to Synthetic Biology | tech talk 2-12-07 | a contrary position on some synthetic bio issues. well worth checking out to be aware of the government and world-wide issues that may shape this field's future. (smolkelab 2007-02-12 16:56:43) | http://www.etcgroup.org/en/materials/publications.html?id=602 | * If a small circle of synthetic biologists get their way, governance of extreme genetic engineering will be left entirely in their hands. * There must be a broad societal debate on synthetic biology’s wider socio-economic and ethical implications, including potential impacts on health, environment, human rights and security. * It is not for scientists to either control public discourse or determine regulatory frameworks. | |||||||||
| Shou2007a | article | Shou, Wenying ; Ram, Sri ; Vilar, Jose | From the Cover: Synthetic cooperation in engineered yeast populations | Proceedings of the National Academy of Sciences | 2007 | Feb | 06 | 104 | 6 | 1877--1882 | tech talk 2-12-07 | 10.1073/pnas.0610575104 | http://www.pnas.org/cgi/content/abstract/0610575104v1 | Cooperative interactions are key to diverse biological phenomena ranging from multicellularity to mutualism. Such diversity makes the ability to create and control cooperation desirable for potential applications in areas as varied as agriculture, pollutant treatment, and medicine. Here we show that persistent cooperation can be engineered by introducing a small set of genetic modifications into previously noninteracting cell populations. Specifically, we report the construction of a synthetic obligatory cooperative system, termed CoSMO (cooperation that is synthetic and mutually obligatory), which consists of a pair of nonmating yeast strains, each supplying an essential metabolite to the other strain. The behavior of the two strains in isolation, however, revealed unintended constraints that restrict cooperation, such as asymmetry in starvation tolerance and delays in nutrient release until near cell death. However, the joint system is shown mathematically and experimentally to be viable over a wide range of initial conditions, with oscillating population ratio settling to a value predicted by nutrient supply and consumption. Unexpectedly, even in the absence of explicitly engineered mechanisms to stabilize cooperation, the cooperative system can consistently develop increased ability to survive reductions in population density. Extending synthetic biology from the design of genetic circuits to the engineering of ecological interactions, CoSMO provides a quantitative system for linking processes at the cellular level to the collective behavior at the system level, as well as a genetically tractable system for studying the evolution of cooperation. | |
| Drubin2007c | article | Drubin, David ; Way, Jeffrey ; Silver, Pamela | Designing biological systems | Genes and Development | 2007 | Feb | 01 | 21 | 3 | 242--254 | review | 10.1101/gad.1507207 | http://www.genesdev.org/cgi/content/full/21/3/242 | ||
| ref110 | article | Light-powering Escherichia coli with proteorhodopsin | Proceedings of the National Academy of Sciences | 2007 | xx | xx | energy | 10.1073/pnas.0611035104 | http://dx.doi.org/10.1073/pnas.0611035104 | ||||||
| Shou2007b | article | Shou, Wenying ; Ram, Sri ; Vilar, J. M. G. | Synthetic cooperation in engineered yeast populations | Proceedings of the National Academy of Sciences | 2007 | Jan | 31 | 0610575104--0610575104 | yeast | 10.1073/pnas.0610575104 | http://www.pnas.org/cgi/content/abstract/0610575104v1 | ||||
| Lim2007 | article | Lim, Han ; Van Oudenaarden, Alexander | A multistep epigenetic switch enables the stable inheritance of DNA methylation states | Nat Genet | 2007 | Feb | xx | 39 | 2 | 269--275 | synthetic biology | 10.1038/ng1956 | http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng1956.html | ||
| ref113 | article | Synthetic biology projects in vitro | Genome Research | 2006 | xx | xx | 17 | 1 | 1--1 | synthetic biology | 10.1101/gr.5776007 | http://www.genome.org/cgi/content/abstract/gr.5776007v1?papetoc | |||
| ref114 | article | Genetic parts to program bacteria | Current Opinion in Biotechnology | 2006 | xx | xx | 17 | 5 | 548--548 | synthetic biology | 10.1016/j.copbio.2006.09.001 | http://dx.doi.org/10.1016/j.copbio.2006.09.001 | |||
| Simpson2006 | article | Simpson, Michael | Cell-free synthetic biology: a bottom-up approach to discovery by design | Mol Syst Biol | 2006 | Dec | 12 | 2 | Cell-Free System | 10.1038/msb4100104 | http://www.nature.com/msb/journal/v2/n1/full/msb4100104.html | ||||
| Kim2006 | article | Kim, Jongmin ; White, Kristin ; Winfree, Erik | Construction of an in vitro bistable circuit from synthetic transcriptional switches | Mol Syst Biol | 2006 | Dec | 12 | 2 | synthetic biology | 10.1038/msb4100099 | http://www.nature.com/msb/journal/v2/n1/full/msb4100099.html | ||||
| ref117 | article | A synthetic multicellular system for programmed pattern formation | Nature | 2005 | xx | xx | 434 | 7037 | 1130--1130 | synthetic biology | 10.1038/nature03461 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15858574 | |||
| ref118 | article | Cellular Logic with Orthogonal Ribosomes | Journal of the American Chemical Society | 2005 | xx | xx | 127 | 50 | 17584--17584 | synthetic biology | 10.1021/ja055338d | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16351070&query_hl=8&itool=pubmed_docsum | |||
| Hasty2002 | article | Hasty, Jeff ; McMillen, David ; Collins, J. | Engineered gene circuits | Nature | 2002 | Nov | 14 | 420 | 6912 | 224--230 | genetic network | 10.1038/nature01257 | http://www.nature.com/nature/journal/v420/n6912/full/nature01257.html | ||
| ref120 | electronic | Zinc Fingers Consortium | genetic network | http://www.zincfingers.org/scientific-background.htm | |||||||||||
| ref121 | article | Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly | Nature Protocols | 2006 | xx | xx | 1 | 4 | 1637--1637 | genetic network | 10.1038/nprot.2006.259 | http://www.nature.com/nprot/journal/v1/n3/full/nprot.2006.259.html | |||
| ref122 | article | Synthetic biology--putting engineering into biology | Bioinformatics | 2006 | xx | xx | 22 | 22 | 2790--2790 | synthetic biology | 10.1093/bioinformatics/btl469 | http://dx.doi.org/10.1093/bioinformatics/btl469 | |||
| Seelig2006 | article | Seelig, Georg ; Soloveichik, David ; Zhang, David ; Winfree, Erik | Enzyme-Free Nucleic Acid Logic Circuits | Science | 2006 | Dec | 08 | 314 | 5805 | 1585--1588 | genetic network | 10.1126/science.1132493 | http://www.sciencemag.org/cgi/content/full/314/5805/1585 | ||
| Forster2006a | article | Forster, Anthony ; Church, George | Synthetic biology projects in vitro | Genome Research | 2006 | Dec | 06 | 5776007--5776007 | synthetic biology | 10.1101/gr.5776007 | http://www.genome.org/cgi/content/abstract/gr.5776007v1?papetoc | ||||
| Atsumi2006 | article | Atsumi, Shota ; Little, John | A synthetic phage \{lambda\} regulatory circuit | Proceedings of the National Academy of Sciences | 2006 | Nov | 29 | 0603052103--0603052103 | synthetic biology | 10.1073/pnas.0603052103 | http://www.pnas.org/cgi/content/abstract/0603052103v1?etoc | ||||
| ref126 | electronic | The New Atlantis - The Promise and Perils of Synthetic Biology - Jonathan B. Tucker and Raymond A. Zilinskas | synthetic biology | http://www.thenewatlantis.com/archive/12/tuckerzilinskas.htm | |||||||||||
| ref127 | electronic | Optimizing Biological Circuits: Integrating Rational Design with Directed Evolution | synthetic biology | http://aiche.confex.com/aiche/2006/preliminaryprogram/abstract_52714.htm | |||||||||||
| Collins2005 | article | Collins, Cynthia ; Arnold, Frances ; Leadbetter, Jared | Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones | Molecular Microbiology | 2005 | xx | xx | 55 | 3 | 712--723 | synthetic biology | 10.1111/j.1365-2958.2004.04437.x | http://www.blackwell-synergy.com/links/doi/10.1111/j.1365-2958.2004.04437.x/enhancedabs/ | ||
| Vilar2006 | article | Vilar, Jose | Modularizing gene regulation | Mol Syst Biol | 2006 | Mar | 21 | 2 | gene expression | 10.1038/msb4100058 | http://www.nature.com/msb/journal/v2/n1/full/msb4100058.html | ||||
| Wolf2003 | article | Wolf, Denise ; Arkin, Adam | Motifs, modules and games in bacteria. | Current opinion in microbiology. | 2003 | Apr | xx | 6 | 2 | 125--134 | synthetic biology | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12732301&dopt=Abstract | |||
| Michnick2006 | article | Michnick, Stephen | A luxRury of synthetic signals | Nat Biotech | 2006 | Jun | xx | 24 | 6 | 658--660 | pLuxR | 10.1038/nbt0606-658 | http://www.nature.com/nbt/journal/v24/n6/full/nbt0606-658.html | ||
| Cookson2005 | article | Cookson, Scott ; Ostroff, Natalie ; Pang, Wyming ; Volfson, Dmitri ; Hasty, And | Monitoring dynamics of single-cell gene expression over multiple cell cycles | Mol Syst Biol | 2005 | Nov | 22 | 1 | 1 | 4100032--4100031 | thesis\_chapter\_2 | 10.1038/msb4100032 | http://www.nature.com/msb/journal/v1/n1/full/msb4100032.html | ||
| Anderson2006 | article | Anderson, J. ; Clarke, Elizabeth ; Arkin, Adam ; Voigt, Christopher | Environmentally controlled invasion of cancer cells by engineered bacteria. | Journal of molecular biology. | 2006 | Jan | 27 | 355 | 4 | 619--627 | synthetic biology | 10.1016/j.jmb.2005.10.076 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16330045&dopt=Citation | ||
| ref134 | electronic | Tuning genetic control through promoter engineering -- Alper et al. 102 (36): 12678 -- Proceedings of the National Academy of Sciences | synthetic biology | http://www.pnas.org/cgi/content/abstract/102/36/12678 | |||||||||||
| Schibler2005 | article | Schibler, Ueli ; Naef, Felix | Cellular oscillators: rhythmic gene expression and metabolism. | Current opinion in cell biology. | 2005 | Apr | xx | 17 | 2 | 223--229 | synthetic biology | 10.1016/j.ceb.2005.01.007 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15780601&dopt=Citation | ||
| Atsumi2004 | article | Atsumi, Shota ; Little, John | Regulatory circuit design and evolution using phage \{lambda\} | Genes and Development | 2004 | Sep | 01 | 18 | 17 | 2086--2094 | synthetic biology | 10.1101/gad.1226004 | http://www.genesdev.org/cgi/content/abstract/18/17/2086 | ||
| Balagadde2005 | article | Balagadde, Frederick ; You, Lingchong ; Hansen, Carl ; Arnold, Frances ; Quake, Stephen | Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat | Science | 2005 | Jul | 01 | 309 | 5731 | 137--140 | synthetic biology | 10.1126/science.1109173 | http://www.sciencemag.org/cgi/content/abstract/309/5731/137 | ||
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| ref224 | article | BioMed Central | Abstract | 1471-2105-7-55 | PathSys: integrating molecular interaction graphs for systems biology | BMC Bioinformatics | 2006 | Feb | 07 | 7 | 1 | 55 | synthetic biology | 10.1186/1471-2105-7-55 | 14712105 | http://dx.doi.org/10.1186/1471-2105-7-55 | ||
| ref225 | electronic | Synthetic Biology in Practice | synthetic biology | http://blog.lib.umn.edu/sali0090/synbio/ | |||||||||||
| ref226 | electronic | General Review Papers - IGEM | synthetic biology | http://parts.mit.edu/wiki/index.php/General_Review_Papers | |||||||||||
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| Boonyarattanakalin2006 | article | Boonyarattanakalin, Siwarutt ; Athavankar, Sonalee ; Sun, Qi ; Peterson, Blake R. | Synthesis of an Artificial Cell Surface Receptor that Enables Oligohistidine Affinity Tags to Function as Metal-Dependent Cell-Penetrating Peptides. | Journal of the American Chemical Society. | 2006 | Jan | 18 | 128 | 2 | 386--387 | synthetic biology | 10.1021/ja056126j | 0002-7863 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16402806&query_hl=1&itool=pubmed_docsum | |
| Rackham2005 | article | Rackham, Oliver ; Chin, Jason W. | A network of orthogonal ribosome x mRNA pairs. | Nature chemical biology. | 2005 | Aug | xx | 1 | 3 | 159--166 | synthetic biology | 10.1038/nchembio719 | 1552-4450 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16408021&query_hl=1&itool=pubmed_docsum | |
| Volgraf2006 | article | Volgraf, Matthew ; Gorostiza, Pau ; Numano, Rika ; Kramer, Richard H. ; Isacoff, Ehud Y. ; Trauner, Dirk | Allosteric control of an ionotropic glutamate receptor with an optical switch. | Nature chemical biology. | 2006 | Jan | xx | 2 | 1 | 47--52 | synthetic biology | 10.1038/nchembio756 | 1552-4450 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16408092&query_hl=1&itool=pubmed_docsum | |
| Simpson2004a | article | Simpson, Michael L. | Rewiring the cell: synthetic biology moves towards higher functional complexity. | Trends Biotechnol | 2004 | Nov | xx | 22 | 11 | 555--557 | synthetic biology | 10.1016/j.tibtech.2004.09.003 | 0167-7799 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15491797&query_hl=4 | |
| ref232 | electronic | Research Papers in Synthetic Biology - IGEM | synthetic biology | http://parts.mit.edu/wiki/index.php/Research_Papers_in_Synthetic_Biology | |||||||||||
| ref233 | electronic | Registry of Standard Biological Parts | synthetic biology | http://parts.mit.edu/ | |||||||||||
| ref234 | electronic | Main Page - IGEM | synthetic biology | http://parts.mit.edu/wiki/index.php/Main_Page | |||||||||||
| ref235 | electronic | SignOnSanDiego.com > News > Science -- Command performances | synthetic biology | http://www.signonsandiego.com/news/science/20051214-9999-lz1c14circuit.html# | ``Controlling organisms with biological circuits, opens up a world of possibilities and dangers'' | ||||||||||
| Chen2005a | article | Chen, Ming-Tang ; Weiss, Ron | Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana | Nature biotechnology. | 2005 | Nov | 20 | advanced online publication | 12 | 1551--1555 | synthetic biology | 10.1038/nbt1162 | 1087-0156 | http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt1162.html | |
| Fung2005 | article | Fung, Eileen ; Wong, Wilson ; Suen, Jason ; Bulter, Thomas ; Lee, Sun-gu ; Liao, James | A synthetic gene-metabolic oscillator | Nature | 2005 | May | 05 | 435 | 7038 | 118--122 | synthetic biology | 10.1038/nature03508 | 0028-0836 | http://www.nature.com/nature/journal/v435/n7038/abs/nature03508.html | |
| Endy2005d | article | Endy, Drew | Foundations for engineering biology | Nature | 2005 | Nov | 24 | 438 | 7067 | 449--453 | synthetic biology | 10.1038/nature04342 | 0028-0836 | http://www.nature.com/nature/journal/v438/n7067/full/nature04342.html | Engineered biological systems have been used to manipulate information, construct materials, process chemicals, produce energy, provide food, and help maintain or enhance human health and our environment. Unfortunately, our ability to quickly and reliably engineer biological systems that behave as expected remains quite limited. Foundational technologies that make routine the engineering of biology are needed. Vibrant, open research communities and strategic leadership are necessary to ensure that the development and application of biological technologies remains overwhelmingly constructive. |
| Levskaya2005b | article | Levskaya, Anselm ; Chevalier, Aaron ; Tabor, Jeffrey ; Simpson, Zachary Booth ; Lavery, Laura ; Levy, Matthew ; Davidson, Eric ; Scouras, Alexander ; Ellington, Andrew ; Marcotte, Edward ; Voigt, Christopher | Synthetic biology: Engineering Escherichia coli to see light | Nature. | 2005 | Nov | 24 | 438 | 7067 | 441--442 | synthetic biology | 10.1038/nature04405 | 1476-4687 | http://www.nature.com/nature/journal/v438/n7067/abs/nature04405.html | |
| Endy2005e | article | Endy, Drew | Foundations for engineering biology | Nature | 2005 | Nov | 24 | 438 | 7067 | 449--453 | synthetic biology | 10.1038/nature04342 | 0028-0836 | http://www.nature.com/nature/journal/v438/n7067/full/nature04342.html | |
| Sprinzak2005b | article | Sprinzak, David ; Elowitz, Michael | Reconstruction of genetic circuits | Nature | 2005 | Nov | 24 | 438 | 7067 | 443--448 | synthetic biology | 10.1038/nature04335 | 0028-0836 | http://www.nature.com/nature/journal/v438/n7067/full/nature04335.html | |
| Levskaya2005c | article | Levskaya, Anselm ; Chevalier, Aaron ; Tabor, Jeffrey ; Simpson, Zachary Booth ; Lavery, Laura ; Levy, Matthew ; Davidson, Eric ; Scouras, Alexander ; Ellington, Andrew ; Marcotte, Edward ; Voigt, Christopher | Synthetic biology: Engineering Escherichia coli to see light - article in Nature | Nature. | 2005 | Nov | 24 | 438 | 7067 | 441--442 | Photography | 10.1038/nature04405 | 1476-4687 | http://www.nature.com/nature/journal/v438/n7067/abs/nature04405.html | We have designed a bacterial system that is switched between different states by red light. The system consists of a synthetic sensor kinase that allows a lawn of bacteria to function as a biological film, such that the projection of a pattern of light on to the bacteria produces a high-definition (about 100 megapixels per square inch), two-dimensional chemical image. This spatial control of bacterial gene expression could be used to 'print' complex biological materials, for example, and to investigate signalling pathways through precise spatial and temporal control of their phosphorylation steps. |
| ref243 | electronic | Bacterial film : Nature | Photography | http://www.nature.com/nature/journal/v438/n7067/edsumm/e051124-07.html | Phytochromes are membrane-bound photoreceptors found in plants and some bacteria. There are none in Escherichia coli, but with the introduction of a genetic circuit that fuses a cyanobacterial photoreceptor to an intracellular kinase, E. coli sees the light. The bacteria then act as a photographic film, producing a chemical image when light is projected onto it. | ||||||||||
| ref244 | electronic | Guardian Unlimited || Super-sensitive film made from living bacteria - on article in Nature | Photography | http://www.guardian.co.uk/science/story/0,3605,1649439,00.html | Scientists have created a new kind of photographic film, made from living bacteria, which is able to detect nano-scale features and print ultra-detailed images. By genetically engineering a common form of bacterium they were able to make it switch its pigment production on and off in response to a light. | ||||||||||
| Endy2005f | article | Endy, Drew | Foundations for engineering biology | Nature | 2005 | Nov | 24 | 438 | 7067 | 449--453 | synthetic biology | 10.1038/nature04342 | 0028-0836 | http://www.nature.com/nature/journal/v438/n7067/pdf/nature04342.pdf | |
| ref246 | electronic | Bacteria can take pictures of themselves - Boston.com - on article in Nature | synthetic biology | http://www.boston.com/news/science/articles/2005/11/23/bacteria_can_take_pictures_of_themselves/ | The notorious E. coli bug made its film debut Wednesday. That's when researchers at the University of California, San Francisco and the University of Texas announced in the journal Nature that they had created photographs of themselves by programming the bacteria -- best known for outbreaks of food poisoning -- to make pictures in much the same way Kodak film produces images. | ||||||||||
| Chen2005b | article | Chen, Ming-Tang ; Weiss, Ron | Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana | Nature biotechnology. | 2005 | Nov | 20 | advanced online publication | 12 | 1551--1555 | synthetic biology | 10.1038/nbt1162 | 1087-0156 | http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt1162.html | |
| Pennisi2005 | article | Pennisi, Elizabeth | SYNTHETIC BIOLOGY: Synthetic Biology Remakes Small Genomes | Science | 2005 | Nov | 04 | 310 | 5749 | 769--770 | synthetic biology | http://www.sciencemag.org/cgi/content/full/310/5749/769 | |||
| ref249 | electronic | Qualitative Reasoning in biology - symposium collection | synthetic biology | http://monet.aber.ac.uk:8080/monet/docs/pdf_files/aime_03/mbqr-aime03.pdf | |||||||||||
| ref250 | electronic | Welcome to Synthetic and Systems Biology | synthetic biology | http://www.ssbjournal.com/ | Journal Homepage | ||||||||||
| ref251 | article | Combining two genomes in one cell: Stable cloning of the Synechocystis PCC6803 genome in the Bacillus subtilis 168 genome | Proceedings of the National Academy of Sciences of the United States of America | 2005 | Nov | 01 | 102 | 44 | 15971--15976 | synthetic biology | 10.1073/pnas.0503868102 | 0027-8424 | http://dx.doi.org/10.1073/pnas.0503868102 | ||
| ref252 | electronic | VIROLOGY: Resurrected Influenza Virus Yields Secrets of Deadly 1918 Pandemic -- Kaiser 310 (5745): 28 -- Science | AvianFlu | http://www.sciencemag.org/cgi/content/summary/310/5745/28 | |||||||||||
| Simpson2004b | article | Simpson, Michael L. | Rewiring the cell: synthetic biology moves towards higher functional complexity. | Trends Biotechnol | 2004 | Nov | xx | 22 | 11 | 555--557 | synthetic biology | 10.1016/j.tibtech.2004.09.003 | 0167-7799 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15491797&query_hl=4 | Nice overview of the present state of the field and some of its future research goals |
| Pedraza2005b | article | Pedraza, Juan M. ; van Oudenaarden, Alexander | Noise propagation in gene networks. | Science (New York, N.Y.) | 2005 | Mar | 25 | 307 | 5717 | 1965--1969 | Synthetic | 10.1126/science.1109090 | 1095-9203 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15790857&query_hl=12 | |
| Elowitz2002 | article | Elowitz, Michael B. ; Levine, Arnold J. ; Siggia, Eric D. ; Swain, Peter S. | Stochastic gene expression in a single cell. | Science | 2002 | Aug | 16 | 297 | 5584 | 1183--1186 | synthetic biology | 10.1126/science.1070919 | 1095-9203 | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12183631&query_hl=7 | |
| Guet2002b | article | <