Talk:20.109(F09):HC^2

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Contents

Overview

Gold nanoparticles can be used to create 3-dimensional structures of DNA. This method of construction precisely controls the shape, size, and orientation of the particles. With conformations from stacked rings to spiral tubes, the possibility of using “DNA tubules” as a new material for nanoscale architecture is possible. The proof of concept for the construction

Research Question: Can we create and engineer nano-components out of DNA? A “DNA nanowire” would be a very tiny strip of negative charges. Does this hold useful applications?

Plan

1. Talk to Angela Belcher about her lab's experience with DNA-based materials. 2. Think of the most promising application. Will this be a DNA-made container for drug delivery? How about DNA-based circuit components?

References

  • Sharma, J et al. “Control of Self-Assembly of DNA Tubules Through Integration of Gold Nanoparticles.” Science 323(2009): 112-116.
  • Goodman, RP et al. "Rapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication." Science 310 (2005): 1661-1665. [Found here]
  • Rothemund, PWK. "Folding DNA to create nanoscale shapes and patterns." Nature 440(2006): 297-302. [Found here]
  • Zheng, J et al. "Two-Dimensional Nanoparticle Arrays Show the Organizational Power of Robust DNA Motifs." Nano Lett 6(7):1502-1504. 2006. [Found here]
  • Harvard iGEM 2006 team's project [their project wiki]
  • Chen, AM et al. "Oligodeoxynucleotide nanostructure formation in the presence of polypropyleneimine dendrimers and their uptake in breast cancer cells." Nanotechnology 17(2006): 5449-5460. [Another source]

Internal Deadlines

  • Fri, Nov 20: Pick and commit to idea
  • Mon, Nov 23: Decide experimental approach
  • Mon, Nov 30: Draft outline, experiments
  • Tue/Wed, Dec 1/2: Get feedback
  • Fri, Dec 4: Make rough draft of presentation
  • Sun/Mon, Dec 6/7: PRACTICE, edit
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