User:Christian G Ramos

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Contents

Contact Info

Christian G Ramos (an artistic interpretation)
Christian G Ramos (an artistic interpretation)
  • Christian G Ramos
  • Gene Expression and Regulation Group
  • BioISI - Biosystems and Integrative Sciences Institute
  • Campo Grande, Edifício C8, Office 8.6.20; Lab 8.3.43C
  • Lisboa, Portugal.
  • Email me through OpenWetWare

I work in the RNA Biology and Bioinformatics Lab[1] as a post-doc and hold and Assistant Professor (invited) position @ DQB/FCUL.

Education

  • 2011, PhD, Instituto Superior Técnico, Universidade Técnica de Lisboa (Molecular Microbiology)
  • 2007, MS, Instituto Superior Técnico, Universidade Técnica de Lisboa (Biotechnology)
  • 2002, BS, Universidade Lusófona de Humanidades e Tecnologias, Lisboa (Biotechnology Engineering)

Research interests

Small noncoding RNAs (sncRNAs) are important regulators of gene expression processes that have been gaining increased relevance both due to their implications in host-pathogen interactions and to their pervasive roles in the regulation of key cellular processes either in prokaryotes or eukaryotes. Several projects focused on sncRNAs and their role in Host-pathogen interactions are ongoing.

Publications

Books

Ramos CG. Unveiling Novel Virulence Factors from Burkholderia cepacia Complex: Exploitation of the Caenorhabditis elegans infection model, Lambert Academic Publishing, Saarbrücken, Germany 2011, (ISBN: 978-3-8454-2283-1); Ramos CG, Grilo AM, Leitão JH. Small non-coding RNAs in Prokaryotes: Roles in Pathogenesis and Potential Therapeutic Targets. Lambert Academic Publishing, Saarbrücken, Germany, 2010 (ISBN: 978-3-8383-2116-5).

Book chapters

1. Leitão JH., Sousa SA, Ramos CG, Feliciano JR, Grilo AM, da Costa PJP. Experimental and bioinformatics approaches to identify new targets for the rational design of antimicrobials against multiresistant bacteria of the Burkholderia cepacia complex. In Microbial pathogens and strategies for combating them: science, technology and education, A. Méndez-Vilas (Ed.), Vol. 1,l pp 372-383. ISBN: 978-84-939843-9-7.

2. Ramos CG, Leitão JH. "Caenorhabditis elegans as a research tool to unveil bacterial virulence determinants: Lessons from the Burkholderia cepacia complex" (Chapter 5). In: Nematodes: Morphology, Functions and Management Strategies. (Editors: Fausto Boeri and Jordan A. Chung) Nova Science Publishers, Inc. 2012 (ISBN: 978-1-61470-867-4);

3. Ramos CG, Grilo AM, da Costa PJP, Nadais H, Leitão JH, "Extraction and Purification of DNA obtained from UASB reactors sludge samples". In: DNA Binding and DNA Extraction: Methods, Applications and Limitations. (Editors: Chunxu Zhou and Xia Ling) Nova Science Publishers, Inc. 2011 (ISBN: 978-1-62100-022-8);

4. Sousa SA, Ramos CG, Feliciano JR, Leitão JH, “Bacterial type II PMIs: exploitable bifunctional enzymes for biotechnological applications and the rational design of antimicrobials” (Chapter 15) in Biopolymers (Edited by Magdy Elnashar), 2010 published by Sciyo (ISBN 978-953-307-109-1).

Articles

1. Ramos CG, Grilo AM, Sousa SA, Feliciano JR, Da Costa PJP and Leitão JH, (2014) Regulation of Hfq mRNA and protein levels in Escherichia coli and Pseudomonas aeruginosa by the Burkholderia cenocepacia MtvR. PLoS ONE 9 (6): e98813


2. Ramos CG, Grilo AM, da Costa PJP, Leitão JH, (2013) Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia, Genomics 101 (2): 139-148;

3. Ramos C.G., Grilo A.M., da Costa P.J.P., Feliciano J.R., Leitão J.H. (2013) “Unveiling the roles of small non-coding RNAs and RNA chaperones on the biology of opportunistic pathogens of the Burkholderia cepacia complex”. Journal of Cystic Fibrosis 12, (S1):S77.

4. Ramos CG*, Grilo AM, Sousa SA, Leitão JH*. (2013) Post-transcriptional regulation of gene expression in the human opportunistic pathogens of the Burkholderia cecepacia complex. Magazine SPM 3 (1): http://magazinespm.wordpress.com/2014/04/21/post-transcription-regulation-by-srnas-and-rna-chaperones/ * Joint corresponding authors.

5. Sousa SA, Ramos CG, Grilo AM, Feliciano JR, da Costa PJP, Leitão JH. (2013), Estratégias de identificação de novos alvos para combater infecções por bactérias do complexo Burkholderia cepacia. Boletim de Biotecnologia. 2 (4): 41-43

6. Ramos CG, (2013) Roles played by Hfq-like RNA chaperones and sRNAs on the virulence of Burkholderia cepacia complex bacteria. Magazine SPM 2 (1): PhD Highlights (http://magazinespm.wordpress.com/2013/03/28/phd-highlights/);

7. Sousa S.A., Soares-Castro P., Feliciano J.R., Ramos C.G., Martinez J.L.C., Santos P.M., Leitão J.H., (2013) “Unveiling the Burkholderia cenocepacia J2315 RNA chaperone Hfq2 interactome”. Journal of Cystic Fibrosis 12, (S1):S77.

8. Sousa S.A., Feliciano J.R., Ramos C.G., Leitão J.H. (2013) “The Burkholderia cenocepacia J2315 small non-coding RNA MavA is required for fitness and virulence”. Journal of Cystic Fibrosis 12, (S1):S76.

9. Pinto-de-Oliveira A., Coutinho C.P., Ramos C.G., Sousa S.A., de Carvalho C.C.C.R., Leitão J.H., Sá-Correia I. (2013) “The Burkholderia cepacia small colony variants (SCV) are a more pathogenic bacterial form that may facilitate persistent respiratory infections in CF patients”. Journal of Cystic Fibrosis 12, (S1):S76.

10. Ramos CG, Da Costa PJP, Döring G, and Leitão JH, (2012) The novel cis-encoded small RNA h2cR is a negative regulator of hfq2 in Burkholderia cenocepacia. PLoS ONE 7(10):e47896;

11. Grilo AM, Ramos CG, Leitão JH, (2012) Identification of regulatory small non-coding RNAs in Burkholderia cenocepacia J2315, FEBS Journal, 279(1), 510-510;

12. Mendes S, Farinha A, Ramos CG, Leitão JH, Viegas CA, Martins LO, (2011) Synergistic Action of Azoreductase and Laccase Leads to Maximal Decolourisation and Detoxification of Model Dye Wastewaters. Bioresource Technology 102 (21): 9852-9859;

13. Sousa SA, Ramos CG, Leitão JH. (2011) Burkholderia cepacia complex: emerging multi-host pathogens equipped with a wide range of virulence factors and determinants. International Journal of Microbiology Vol. 2011 , Article ID 607575;

14. Mendes S, Farinha A, Ramos CG, Leitão JH, Viegas CA, Martins LO, (2011) Synergistic Action of Azoreductase and Laccase Leads to Maximal Decolourisation and Detoxification of Model Dye-containing Wastewaters. Environmental Engineering and Management Journal 11 (3) Supplement: S1.1 (S4)

15. Nadais H, Barbosa M, Capela I, Arroja L, Ramos CG, Grilo AM, Sousa SA, Leitão JH. (2011) Enhancing Wastewater Degradation and Biogas Production by Intermittent Operation of UASB Reactors. Energy. 36: 2164-2168;

16. Leitão JH, Sousa SA, Ferreira AS, Ramos CG, Silva IN, Moreira LM. (2010) Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepacia complex pathogens and related species. Applied Microbiology and Biotechnology 87: 31-40;

17. Ramos CG, Sousa SA, Grilo AM, Eberl L, Leitão JH. (2010) The Burkholderia cenocepacia K56-2 pleiotropic regulator Pbr, is required for stress resistance and virulence. Microbial Pathogenesis 48: 168-177;

18. Sousa SA*, Ramos CG*, Moreira LM, Leitão JH. (2010) The hfq gene is required for stress resistance and full virulence of Burkholderia cepacia to the nematode Caenorhabditis elegans. Microbiology 156: 896–908. *Shared first authorship;

19. Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM. (2010) Distribution of Cepacian Biosynthetic Genes among Environmental and Clinical Strains of the Burkholderia Genus and Role of this Exopolysaccharide on Resistance to Stress Conditions. Applied and Environmental Microbiology 76: 441-450;

20. Ramos CG, Grilo AM, Sousa SA, Barbosa ML, Nadais H, Leitão JH. (2010) A new methodology combining PCR, cloning and sequencing of clones discriminated by RFLP for the study of microbial populations: application to an UASB sample", Applied Microbiology and Biotechnology 85: 801-806;

21. Grilo AM, Ramos CG, Sousa SA, Barbosa ML, Nadais H, Leitão JH. (2010), Caracterização molecular de populações microbianas em reactores anaeróbios para o tratamento de efluentes. Boletim de Biotecnologia. 85: 3-9;

22. Sousa SA, Ramos CG, Almeida F, Meirinhos-Soares L, Wopperer J, Schwager S, Eberl L, Leitão JH. (2008) Burkholderia cenocepacia j2315 acyl carrier protein: a potential target for antimicrobials development?, Microbial Pathogenesis 45, 331-336;

23. Ramos CG, Sousa SA, Leitão JH. (2008), Identification and characterization of a phenazine biosythetic locus required for virulence of Burkholderia cenocepacia K56-2 to the nematode Caenorhabditis elegans, FEBS Journal, 275 (S1): 275;

24. Ramos CG, Simões S. (2006) Métodos para a identificação de Escherichia coli na Indústria Alimentar. Revista Portuguesa de Ciencias Veterinárias 101: 131-132;

25. Ramos CG, Costa MT. (2006) Patterns of resistance to beta-lactams and beta-lactamase inhibitors in uropathogenic Escherichia coli isolated from animals in Portugal. African Journal of Biotechnology 5: 523-525.

Proceedings

1. Grilo A. M., Ramos C.G., Sousa S. A., Arroja L, Capela I., Leitão J.H., Nadais H. (2011) Optimizing energy production from wastewater by intermittent operation of anaerobic reactors. 19th European Biomass Conference and Exibition. Berlin, Germany

2. Grilo AM, Ramos CG, Sousa SA, Arroja LG, Capela IF, Leitao JH, Nadais HG: "Microbial population shifts as a tool for improving biogas production in anaerobic reactors", In CEST2011: A-625-629, (Sep 2011), Rhodes, Greece.

3. Ramos CG, Sousa SA, Grilo AM, da Costa PJP, Feliciano JR, Leitão JH. (2011) A RNomics-based strategy identifies regulatory small RNAs in Burkholderia cepacia complex. Proceedings of the First Portuguese Meeting in Bioengineering, 1-4 March, IST, TagusPark, Oeiras, Portugal;

4. Sousa SA, Ramos CG, Feliciano JR, Leitão JH. (2011) Identification and exploitation of Burkholderia cepacia complex virulence factors as potential antimicrobial targets. Proceedings of the First Portuguese Meeting in Bioengineering, 1-4 March, IST, TagusPark, Oeiras, Portugal;

5. Barbosa M, Ramos CG, Grilo AM, Sousa SA, Capela I, Arroja L, Leitão JH, Nadais H. (2009) Bioenergy production from complex wastewaters, Proceedings of the 5th International Conference on Energy, Environment, Ecosystems and Sustainable Development (EEESD '09), Vouliagmeni, Athens, Greece, September 28-30, 2009. Energy and Environmental Engineering Series, Published by WSEAS Press. ISSN: 1790-5095, ISBN: 978-960-474-125-0.

Useful links

  • [Linkedin [2]]
  • [Scopus [3]]
  • [OrciD [4]]
  • [Researcher ID [5]]
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