User:Dianab

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Diana Borenshtein

Diana

Bio

Research

I developed and characterized an animal model of fatal diarrhea and colitis in FVB mice infected with the natural mouse pathogen Citrobacter rodentium. I implemented different methods for preventing and/or treating morbidity and mortality in C. rodentium-infected FVB mice. Based on gene expression profiling using high-density DNA microarrays, I proposed novel mechanisms of host susceptibility to C. rodentium-induced fatal diarrhea. These mechanisms were validated in subsequent animal studies in inbred strains of mice.

The goal of my current research is to characterize the effects of intestinal bacterial infection at the level of the whole organism and to establish the mechanisms by which acute infectious colitis can contribute to the development of metabolic disorders in a long-term.

My other interests include studying genomic instability in murine colons, investigating the effect of bacterial infection in base excision repair deficient mice and other projects related to colon carcinogenesis.

Contact

MIT 56-786

diana_b@mit.edu

Publications

Borenshtein D, Fry RC, Groff EB, Nambiar PR, Carey VJ, Fox JG, Schauer DB. Diarrhea as a cause of mortality in a mouse model of infectious colitis. Genome Biol 2008; 9: R122.

• Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest 2008; 118: 2516-25.

Borenshtein D, McBee ME, Schauer DB. Utility of the Citrobacter rodentium infection model in laboratory mice. Curr Opin Gastroenterol 2008; 24: 32-7.

Borenshtein D, Nambiar PR, Groff EB, Fox JG, Schauer DB. Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Infect Immun 2007; 75: 3271-81. (cover image in July issue).

Borenshtein D, Schauer DB. The genus Citrobacter. In, M. Dworkin et al., eds., The Prokaryotes: An Evolving Electronic Resource for the Microbiological Community, 3rd edition, Springer-Verlag, New York (Release 3.18, 2004).

• Stark AH, Ilan E, Timar B, Borenshtein D, Madar Z. Alpha lipoic acid inhibits glycogen synthesis and modifies glucose metabolism and signaling pathways in soleus muscles from healthy rats. Nutraceuticals and Food 2002; 7: 113-118.

Borenshtein D, Ofri R, Werman M, Stark A, Tritschler HJ, Moeller W, Madar Z. Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate. Diabetes Metab Res Rev 2001; 17: 44-50.

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