User:Omar F. Khan
Omar F. Khan
Hi, my name is Omar F. Khan, and I'm currently at the Massachusetts Institute of Technology. I work in the labs of Professors Robert Langer and Daniel G. Anderson within the David H. Koch Institute for Integrative Cancer Research. I did my PhD in Chemical Engineering at the University of Toronto under the supervision of Professor Michael V. Sefton.
I work towards the treatment of damaged tissues and organs by combining nanotechnology and tissue engineering. Currently, my work is featured in the Koch Institute Public Galleries at MIT. To see a brief video of me describing some of my nanotechnology work, click here.
Postdoctoral Associate, Langer and Anderson Labs, Massachusetts Institute of Technology
Ph.D., Chemical Engineering and Applied Chemistry/Institute of Biomaterials and Biomedical Engineering, University of Toronto, 2010
B.A.Sc.(with honors), Chemical Engineering, University of Toronto, 2004
Publications and Communications
Khan, O.F., Zaia, E.W., Jhunjhunwala, S., Pelet, J.M., Webber, M.J., Xue, W., Cai, W., Yun, D.S., Tsosie, J., Dong, Y., Barnes, C., Dahlman, J.E., Jacks, T.E., Langer, R. and Anderson, D.G. In vivo delivery of siRNA to lung endothelial cells using dendrimer-inspired nanomaterials. Nano Letters. Submitted.
Sharei, A., Trifonova, R., Jhunjhunwala, S., Hartoularos, G.C., Eyerman, A.T., Lytton-Jean, A., Angin, M., Sharma, S., Poceviciute, R., Mao, S., Heimann, M., Liu, S., Talkar, T., Khan, O.F., Addo, M., von Andrian, U.H., Anderson, D.G., Langer, R., Lieberman, J., Jensen, K.F. Ex vivo cytosolic delivery of functional macromolecules to immune cells. PLOS ONE. Submitted.
White, K., Lu, Y., Annis, S., Hale, A.E., Chau, B.N., Dahlman, J.E., Hemann, C., Opotowsky, A.R., Vargas, S.O., Rosas, I., Perrella, M.A., Osorio, J.C., Haley, K.J., Graham, B.B., Kuman, R., Saggar, R., Saggar, R., Wallace, W.D., Ross, D.J., Khan, O.F., Bader, A., Gochuico, B.R., Matar, J., Polach, K., Johannessen, N.M., Anderson, D.G., Langer, R., Zweier, J.L., Bindoff, L.A., Systrom, D., Waxman, A.B., Jin, R.C. and Chan, S.Y. Genetic and hypoxic alterations of the miR-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Molecular Medicine. In revision.
Khan, O.F., Zaia, E.W., Yin, H., Bogorad, R.L., Pelet, J.M., Webber, M.J., Zhuang, I., Dahlman, J.E., Langer, R. and Anderson, D.G. Ionizable amphiphilic dendrimer-based nanomaterials with alkyl chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo. Angewandte Chemie International Edition. 2014. In Press.
Webber, M.J, Khan, O.F., Sydlik, S.A., Tang, B.C. and Langer, R. A perspective on the clinical translation of scaffolds for tissue engineering. Annals of Biomedical Engineering. 2014. In Press.
Xue, W., Dahlman, J.E., Tammela, T., Khan, O.F., Sood, S., Dave, A., Cai, W., Chirino, L.M., Yang,G.R., Bronson, R., Crowley, D.G., Sahay,G., Schroeder, A., Langer, R., Anderson, D.G., Jacks, T. Small RNA combination therapy for lung cancer. The Proceedings of the National Academy of Sciences of the United States of America. 2014. In press.
Khan, O.F., Voice, D.N., Leung, B.M. and Sefton, M.V. A Novel High-Speed Production Process to Create Modular Components for the Bottom-Up Assembly of Large-Scale Tissue-Engineered Constructs. Advanced Healthcare Materials. 2014. In press.
Dahlman, J.E., Barnes, C., Khan, O.F., Thiriot, A., Jhunjunwala, S., Shaw, T.E., Xing, Y., Sager, H.B., Sahay, G., Speciner, L., Bader, A., Bogorad, R.L., Yin, H., Racie, T., Dong, Y., Jiang, S., Seedorf,S. Dave, A., Sandu, K.S., Webber, M.J., Novobrantseva, T., Ruda, V.M., Lytton-Jean, A.K.R., Levins, C.G., Kalish, B., Mudge, D.K., Perez, M., Abezgauz, L., Dutta, P., Smith, S., Charisse, K., Kieran, M.W., Fitzgerald, K., Nahrendorf, M., Danino, D., Tuder, R.M., von Andrian, U.H., Akinc, A., Schroeder, A., Panigrahy, D., Koteliansky, V., Langer, R.S., and Anderson, D.G. Low molecular weight polymeric materials for nanoparticle-mediated in vivo endothelial siRNA delivery. Nature Nanotechnology. 2014. In press.
Dong, Y., Eltoukhy, A.A., Alabi, C.A., Khan, O.F., Veiseh, O., Dorkin, J.R., Sirirungruang, S., Yin, H., Tang, B.C., Pelet, J.M., Chen, D., Zhen, G., Xue, Y., Langer, R.S. and Anderson, D.G. Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo. Advanced Healthcare Materials. 2014. In press.
Khan, O.F., Chamberlain, M.D. and Sefton, M.V. Toward an in vitro vasculature: differentiation of mesenchymal stromal cells within an endothelial cell-seeded modular construct in a microfluidic flow chamber. Tissue Engineering Part A. 2012 Apr;18(7-8):744-56
Khan, O.F. and Sefton, M.V. Endothelialized biomaterials for tissue engineering applications in vivo. Trends in Biotechnology, 2011 Aug;29(8):379-87.
Khan, O.F. and Sefton, M.V. Patterning collagen/poloxamine-methacrylate hydrogels for tissue engineering-inspired microfluidic and laser lithography applications. Journal of Biomaterials Science: Polymer Edition. 2011 Jan;22(18): 2499-2514
Chamberlain, M.D., Butler, M.J., Ciucurel, E.C., Fitzpatrick, L.E., Khan, O.F., Leung, B.M., Lo, C., Patel, R., Velchinskaya, A., Voice, D.N. and Sefton, M.V. Fabrication of Micro-Tissues using Modules of Collagen Gel Containing Cells. Journal of Visualized Experiments, DOI: 10.3791/2177
Khan, O.F. and Sefton, M.V. Endothelial Cell Behaviour within a Microfluidic Mimic of the Flow Channels of a Modular Tissue Engineered Construct. Biomedical Microdevices, 2011 Feb;13(1):69-87.
Khan, O.F. and Sefton, M.V. Perfusion and Characterization of an Endothelial Cell-Seeded Modular Tissue Engineered Construct Formed in a Microfluidic Remodeling Chamber. Biomaterials, 2010 Nov;31(32):8254-61
Khan, O.F., Jean-Francois, J. and Sefton, M.V. MMP Levels in the Response to Degradable Implants in the Presence of a Hydroxamate-Based Matrix Metalloproteinase Sequestering Biomaterial In Vivo. Journal of Biomedical Materials Research, Part A, 2010 Jun 15;93(4):1368-79.
Sosnik A., Khan O.F., Butler M, Sefton M.V.: Poloxamine hydrogels: From non-cell adhesive substrates to matrices with improved cytocompatibility for Tissue Engineering applications. In Barbucci, R. (Ed.), Hydrogels: Biological Properties and Applications. Springer; 2009.
Khan, O.F., Chamberlain, M.D., Dahlman, J.E., Sefton, M.V., Langer, R.S. and Anderson, D.G. "Modular Tissue Containing Endothelial and Mesenchymal Stem Cells formed in a Microfluidic Perfusion Chamber." The 11th US-Japan Symposium on Drug Delivery Systems Conference, Lahaina, Maui, USA, December 16-20, 2011. Poster Presentation
Voice, D.N., Khan, O.F., Leung, B.M. and Sefton, M.V. “High throughput module production and applications to cardiac tissue engineering.” Ontario-on-a-Chip, Toronto, Ontario, Canada, June 9-10, 2011. Poster Presentation
Voice, D.N., Khan, O.F., Leung, B.M. and Sefton, M.V. “A novel plug flow process for high throughput modular tissue engineering.” Canadian Biomaterials Society, 29th Annual Conference, Vancouver, British Columbia, Canada, June 1-4, 2011. Oral presentation
Khan, O.F., Chamberlain, M.D. and Sefton, M.V. “Modular Tissue Containing Endothelial Cells and Mesenchymal Stem Cells formed in a Microfluidic Perfusion Chamber.” Tissue Engineering and Regenerative Medicine International Society (TERMIS)-European Union Chapter Meeting, Galway, Ireland, June 13-17, 2010. Oral Presentation
Khan, O.F., Leung, B.M. and Sefton, M.V. “Modular Cardiac Tissue Containing Endothelial and Cardiomyocyte Cells formed in a Microfluidic Perfusion Chamber,” Ontario-on-a-Chip, Toronto, ON., Canada, May 20-21, 2010. Oral Presentation
Khan, O.F. and Sefton, M.V. “Collagen/Poloxamine Microfluidic Flow Circuits to Characterize Surface-Attached Endothelial Cells Under Flow.” 8th World Biomaterials Congress, Amsterdam, The Netherlands, May 28-June 1, 2008. Oral Presentation
Khan, O.F. and Sefton, M.V. “In Vivo Use of a Matrix Metalloproteinase-Sequestering Biomaterial to Alter the Inflammatory Response,” Regenerate World Congress on Tissue Engineering and Regenerative Medicine, Pittsburgh, Pennsylvania, USA, April 23-27, 2006. Poster Presentation
Khan, O.F. and Sefton, M.V. “In Vivo Alteration of the Foreign Body Response Using a Matrix Metalloproteinase-Sequestering Biomaterial,” Challenges in Regenerative Medicine (ChaRM), Toronto, Ontario, Canada, October 20-21, 2005. Poster Presentation
Patents and Inventions
Khan, O.F., Zaia, E.W., Langer, R.S. and Anderson, D.G. Modified poly(ether sulfone) materials with improved angiogenic responses in vivo. MIT case ID 16924
Khan, O.F., Langer, R.S. and Anderson, D.G. Methodology for producing insulin-secreting devices using a modular approach. MIT case ID 16925
Khan, O.F., Dahlman, J.D., Dong, Y., Anderson, D.G. and Langer, R.S. Degradable and non-degradable dendrimer-based lipidoids and uses thereof. MIT case ID 16054