User:Tkadm30/Notebook/Dopamine

Dopamine transcription factors

• Nurr1 [1]
  • Nurr1 agonists (THC?)
  • Neuroprotection [2]
  • Dopaminergic neurons activation is mediated by Nurr1 gene expression
  • RNA-guided transcriptional regulation of dopamine
• Notch1 [3]
  • Role of Notch1 signaling in striatal dopaminergic neuroprotection?

RNA-guided dopamine neurotransmission

• Nurr1-mediated RNA transcription may autoregulate dopamine D2 receptor density. (Reference needed)

References

1. https://www.ncbi.nlm.nih.gov/pubmed/12846974

   Transcription factors in the development of midbrain dopamine neurons.

2. https://www.ncbi.nlm.nih.gov/pubmed/19345183

   A Nurr1 pathway for neuroprotection.

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416667/

   Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling

4. https://www.ncbi.nlm.nih.gov/pubmed/17506860

   Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro.

5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696720/

   Absent without leave; a neuroenergetic theory of mind wandering

See also

• https://en.wikipedia.org/wiki/Notch_1
• https://en.wikipedia.org/wiki/Notch_signaling_pathway