User:Todd Ciche

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Contact Info

Todd Ciche (an artistic interpretation)

• Todd Ciche, Assistant Professor
• Michigan State University
• Microbiology and Molecular Genetics
• 2215 Biomedical Physical Sciences
• East Lansing, MI, USA.
• Email me through OpenWetWare

I am the PI of the Ciche lab at Michigan State University. I learned about OpenWetWare from interests in synthetic biology originating while a postdoctoral fellow at Caltech (Sternberg lab). I've joined because I believe in the open exchange of protocols, reagents and ideas.

Education

• 2003-2005, Postdoctoral fellow, Sternberg lab, Caltech
• 2000-2003, Postdoctoral fellow, Epel lab, Stanford
• 2000, PhD, Bacteriology, Jerry Ensign adviser, University of Wisconsin-Madison
• 1994, BS, Bacteriology, University of Wisconsin-Madison

Research interests

1. Use of tractable invertebrate models to determine how microbial symbioses develop.
2. Functional genomic analysis of Heterorhabdits bacteriophora nematodes.
3. Host specificity and the evolution of virulence in Photorhabdus luminescens and Burkholderia

Publications

1. Ciche TA, Kim KS, Kaufmann-Daszczuk B, Nguyen KC, and Hall DH. Cell Invasion and Matricide during Photorhabdus luminescens Transmission by Heterorhabditis bacteriophora Nematodes. Appl Environ Microbiol 2008 Apr; 74(8) 2275-87. doi:10.1128/AEM.02646-07 pmid:18281425. PubMed HubMed [Paper1]
2. Ciche T. The biology and genome of Heterorhabditis bacteriophora. WormBook 2007 Feb 20 1-9. doi:10.1895/wormbook.1.135.1 pmid:18050499. PubMed HubMed [Paper2]
3. Ciche TA and Sternberg PW. Postembryonic RNAi in Heterorhabditis bacteriophora: a nematode insect parasite and host for insect pathogenic symbionts. BMC Dev Biol 2007 Sep 5; 7 101. doi:10.1186/1471-213X-7-101 pmid:17803822. PubMed HubMed [Paper3]
4. Hallem EA, Rengarajan M, Ciche TA, and Sternberg PW. Nematodes, bacteria, and flies: a tripartite model for nematode parasitism. Curr Biol 2007 May 15; 17(10) 898-904. doi:10.1016/j.cub.2007.04.027 pmid:17475494. PubMed HubMed [Paper4]
5. Ciche TA, Blackburn M, Carney JR, and Ensign JC. Photobactin: a catechol siderophore produced by Photorhabdus luminescens, an entomopathogen mutually associated with Heterorhabditis bacteriophora NC1 nematodes. Appl Environ Microbiol 2003 Aug; 69(8) 4706-13. pmid:12902261. PubMed HubMed [Paper5]
6. Ciche TA and Ensign JC. For the insect pathogen Photorhabdus luminescens, which end of a nematode is out?. Appl Environ Microbiol 2003 Apr; 69(4) 1890-7. pmid:12676661. PubMed HubMed [Paper6]
7. Ciche TA, Bintrim SB, Horswill AR, and Ensign JC. A Phosphopantetheinyl transferase homolog is essential for Photorhabdus luminescens to support growth and reproduction of the entomopathogenic nematode Heterorhabditis bacteriophora. J Bacteriol 2001 May; 183(10) 3117-26. doi:10.1128/JB.183.10.3117-3126.2001 pmid:11325940. PubMed HubMed [Paper7]