X-Lab

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X-Laboratory

(跨膜信号研究组)

Principle Investigator: Xiaodong LIU, Ph.D. (刘晓冬)

Department of Biomedical Engineering, School of Medicine
IDG/McGovern Institute for Brain Research
School of Life Sciences
at Tsinghua University




Welcome to the X-Lab!


LAB DESCRIPTION

Our research has been in the field of ion channels, focusing on subthreshold or non-spiking behaviors and favoring concepts and methods from synthetic electrophysiology. Major interests are on in-depth biophysical mechanisms of ion channel functions, pursued by applying both biological and engineering principles onto biological entities (synthetic channel subunits & modulators etc.) and physical components (electrical & optical materials, devices, instruments, etc.) exogenously coupled with excitable membranes for the reconstitution of ion channels’ functionality & pathophysiology. We are particularly attracted by the amazing capabilities of ion channels in sensing exogenous stimuli of diverse modality, such as transmembrane potentials, ionic signals, mechanical forces and electromagnetic radiations. How exactly would ion channels sense, transduce and encode the stimuli (i.e., energy and information) at submolecular, molecular and cellular levels? Based on these core biophysics, we pursue mechanistic understanding, pathophysiological ramifications and bioengineering innovations, of transmembrane signalings via ion channels, especially those related to neural information processing (sensory functions and neural oscillations), and those crucial to neural plasticity (CaV channels and Ca2 + signaling). The methodologies span from electrophysiology, biochemistry, molecular biology and optical imaging to biophysical modeling and engineering design & analysis.


Representative Work





X-LAB博士生在2015年第五届国际离子通道大会上获得Excellent Poster Award


X-LAB博士生在2015年中以双边离子通道学术会议上获得Excellent Poster Award


X-LAB本科毕业设计获评2014年清华大学优秀毕业论文


X-LAB博士生在2014第十届全国钙信号会议(CSCS)上获评最佳墙报奖


X-LAB本科毕业设计获得清华学堂班2014最佳科研成果奖


X-LAB博士生获得清华大学短期出国访学基金


X-LAB博士后获评CLS优秀博士后基金


X-LAB博士后获评54期中国博士后基金


X-LAB本科生获评2013年优秀毕业论文


X-LAB硕士生获得2011年国际生物物理年会Best Poster Award


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