CHE.496/2009/Responses/a12

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CHE.496: Biological Systems Design Seminar

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Systems biology and synthetic biology

  • Discussion leader: Brandon

Thaddeus Webb's Response

Systems biology as a foundation for genome-scale synthetic biology

Offers ideas about how synthetic and systems biology will come together. The goal of reconstruction would be the composition of a mathematical model describing all of the parts of a biological system accurately. Currently use stoichiometric matrix for reconstruction. Will benefit from high input data experiments Will need to define parameters to turn reconstructions into models Software and computing will drive synthetic biology. Until models are extremely accurate systems will require the use of directed evolution to be tuned. Tying optimization to growth is an effective way to direct evolution.

Network Benchmarking: A Happy Marriage between Systems and Synthetic Biology

Outlines the mutualism between synthetic and systems biology. Systems biology modeling will enable synthetic design. A five gene system was created

  • Had well defined parts
  • robust against cellular inputs
  • interesting abilities
  • easy external control

Designers used this network to estimate parameters. Thaddeus Webb 23:05, 1 April 2009 (EDT)

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