Min-Ho Kim Lab: Difference between revisions

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<h1>Welcome to the Kim's research group at Kent State University</h1>
<font size=3> The major focus of research interests in our laboratory is to develop nanomedicine strategies towards the treatment of various diseases such as bacterial infections, chronic wounds, and neurological disorders. Nanomedicine is a branch of medicine that applies the knowledge and tools of nanotechnology to the prevention and treatment of disease, which involves the use of nanoscale materials,such as biocompatible nanoparticles. My laboratory develops or utilizes various types of nanoparticles by means of harnessing their unique physicochemical properties for the purpose of either directly targeting pathogens such as multidrug-resistant bacteria, disrupting misfolded proteins such as amyloid plaques, or modifying pro-inflammatory environment of diseased tissue towards an anti-inflammatory and tissue regenerative environment. </font>
 
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<h1>Welcome to the Kim's research group at Kent State University</h1>
<h2> Prospective Students</h2>
<font size=3> The major focus of research interests in our laboratory is to develop therapeutics to promote the resolution of non-healing chronic wounds based on precise understanding of inflammatory response to tissue injury and infection. Many non-healing chronic wounds have been associated with chronic inflammation. A more detailed understanding of mechanisms controlling the inflammatory response and how inflammation directs the outcome of the healing process will provide therapeutics for tissue repair in chronic inflammatory diseases. Our long-term goals are to (1) understand the molecular and cellular mechanisms by which local inflammatory environmental cues alter phenotypic switch of tissue infiltrating innate immune cells and these cells functionally interact with mesenchymal stem cells, and (2) develop selective strategy to engineer microenvironmental cues towards tissue regeneration by utilizing micro/nano-engineered biomaterials that enable spatio-temporal control of inflammatory response. To achieve this goal, we combine interdisciplinary approaches of immuno-biology, stem cell biology, cellular and tissue engineering, and nano-bioengineering. </font>
<font size=3> A prospective graduate student (PhD program in Biological Sciences): We are seeking a highly motivated graduate student who is interested in participating to a NIH-funded project for developing therapeutics for Alzheimer’s disease. In this project, a student will engage in a study to understand the pathophysiological mechanism for microglia-mediated clearance of beta-amyloid plaques. A prospective student who is interested in either neuroscience or immunology should send a CV and a brief statement of research interest to mkim15@kent.edu. </font>


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<h1> Featured News</h1>  
<h1> Featured News</h1>  
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* August 2017- Our manuscript entitled "Glycoprotein non-melanoma clone B regulates the crosstalk between macrophages and mesenchymal stem cells towards wound repair" is accepted for publication in the ''Journal of Investigative Dermatology''. <br>  
* May 2022, Kim lab is awarded with a NIH R01 grant from NIA for investigating magneto-thermal brain stimulation towards the rescue of beta-amyloid pathology, as a potential therapeutic for Alzheimer's disease.[https://www.kent.edu/research/news/min-ho-kim-ph-d-and-woo-yang-kim-ph-d-awarded-research-alzheimers-disease-treatments [Link her for more info]]<br>
* October 2016, Talib received the Poster Award at the 2016 Heal Ohio Conference. Congratulation for the achievement.<br>
* February 2021, Kim lab's research on the development of new synthetic antimicrobial compound to overcome the development of drug resistance is featured  [https://www.kent.edu/research/news/kent-state-researchers-challenge-growing-antibiotic-resistant-bacteria-problem-new?utm_source=kentstatetoday&utm_medium=email&utm_campaign=KST_FEB_11_2021 [Link here for more info]]<br>
* January 2016, Bing Yu is selected as a finalist for Young Investigator Award at the 2016 Wound Healing Society Meeting. Congratulation for the achievement.<br>
* January 2021, Kim lab is awarded with a Brain Health Research Institute (BHRI) pilot grant to validate mild magnetic nanoparticle hyperthermia as a strategy to target amyloid beta plaques in animal model of Alzheimer's disease.
* April 2015, Kim lab is awarded with NIH R01 grant from NINR to pursue a project to develop non-invasive magnetic nanothermotherapy platform for the treatment of wound biofilm infection.[http://www.kent.edu/kent/news/kent-state-biological-sciences-researcher-receives-18-million-nih-grant-chronic-wound [Link here for more info]]<br>
* November 2020, Kim lab is awarded with TeCK Fund grant to develop topical antimicrobial creams towards the treatment of skin and soft tissue MRSA infections.
* March 2015, Bing Yu is awarded with New Investigator Recognition Award at the 2015 Orthopaedic Research Society meeting.[http://www.ors.org/blog/2000/11/21/ors-new-investigator/ [Link here]]<br>
* September 2018, Kim lab is awarded with a new NIH supplement grant to pursue a project to develop targeted magnetic nanoparticle hyperthermia that can target amyloid beta plaques towards the treatment of Alzheimer's disease.
* Feb. 2015, Our manuscript entitled "Biodegradable colloidal microgels with tunable thermosensitive volume phase transitions for controllable drug delivery" is published in the ''Journal of Colloid and Interface Science'', 450:23-33, 2015. [http://www.sciencedirect.com/science/article/pii/S0021979715002441/ [Link here]]<br>
* April 2015, Kim lab is awarded with a NIH R01 grant from NINR to pursue a project to develop non-invasive magnetic nanothermotherapy platform for the treatment of wound biofilm infection.[http://www.kent.edu/kent/news/kent-state-biological-sciences-researcher-receives-18-million-nih-grant-chronic-wound [Link here for more info]]<br>
* Feb. 2014- Our manuscript entitled "Catecholamine stress alters neutrophil trafficking and impairs wound healing via β2 adrenergic receptor mediated upregulation of IL-6" is published in the ''Journal of Investigative Dermatology'', 134:809-817, 2014. [http://www.nature.com/jid/journal/v134/n3/full/jid2013415a.html [Link here]]<br> 
 
* Nov. 2013- Our manuscript entitled "Magnetic nanoparticle targeted hyperthermia of cutaneous S. aureus infection" is published in the ''Annals of Biomedical Engineering'', 41:598-609, 2013
* Apr 2013- Dr. Kim is selected as a recipient of Farris Family Innovation Award to engage research on developing nanothermotherapy platform to target bacterial biofilms in diabetic wounds
* Nov 2012- Dr. Kim is selected as a recipient of Kent State Postdoc Seed Program Award for collaborative projects between Kent State and NEOMED
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Latest revision as of 13:43, 25 September 2022

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Welcome to the Kim's research group at Kent State University

The major focus of research interests in our laboratory is to develop nanomedicine strategies towards the treatment of various diseases such as bacterial infections, chronic wounds, and neurological disorders. Nanomedicine is a branch of medicine that applies the knowledge and tools of nanotechnology to the prevention and treatment of disease, which involves the use of nanoscale materials,such as biocompatible nanoparticles. My laboratory develops or utilizes various types of nanoparticles by means of harnessing their unique physicochemical properties for the purpose of either directly targeting pathogens such as multidrug-resistant bacteria, disrupting misfolded proteins such as amyloid plaques, or modifying pro-inflammatory environment of diseased tissue towards an anti-inflammatory and tissue regenerative environment.

Prospective Students

A prospective graduate student (PhD program in Biological Sciences): We are seeking a highly motivated graduate student who is interested in participating to a NIH-funded project for developing therapeutics for Alzheimer’s disease. In this project, a student will engage in a study to understand the pathophysiological mechanism for microglia-mediated clearance of beta-amyloid plaques. A prospective student who is interested in either neuroscience or immunology should send a CV and a brief statement of research interest to mkim15@kent.edu.

Featured News

  • May 2022, Kim lab is awarded with a NIH R01 grant from NIA for investigating magneto-thermal brain stimulation towards the rescue of beta-amyloid pathology, as a potential therapeutic for Alzheimer's disease.[Link her for more info]
  • February 2021, Kim lab's research on the development of new synthetic antimicrobial compound to overcome the development of drug resistance is featured [Link here for more info]
  • January 2021, Kim lab is awarded with a Brain Health Research Institute (BHRI) pilot grant to validate mild magnetic nanoparticle hyperthermia as a strategy to target amyloid beta plaques in animal model of Alzheimer's disease.
  • November 2020, Kim lab is awarded with TeCK Fund grant to develop topical antimicrobial creams towards the treatment of skin and soft tissue MRSA infections.
  • September 2018, Kim lab is awarded with a new NIH supplement grant to pursue a project to develop targeted magnetic nanoparticle hyperthermia that can target amyloid beta plaques towards the treatment of Alzheimer's disease.
  • April 2015, Kim lab is awarded with a NIH R01 grant from NINR to pursue a project to develop non-invasive magnetic nanothermotherapy platform for the treatment of wound biofilm infection.[Link here for more info]
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