Yeo lab:solvent exchange

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Laboratory for Therapeutic Particle Engineering

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GROWTH FACTOR DELIVERY for tissue engineering

Although transplantation has saved countless lives, it is severely limited by donor shortage. Tissue engineering has been explored as a promising tool for alleviating the shortage of tissues and organs by providing artificial alternatives. In vitro tissue engineering requires 3-dimensional environment that can support attachment of target cells and provide timely chemical stimuli to promote their growth and differentiation. To this end, we aim to develop a composite scaffold consisting of a biocompatible hydrogel and growth factor-eluting microcapsules. One of the main challenges in developing such a scaffold is the lack of a protein delivery system that can encapsulate and release the growth factors with high efficiency. We will utilize the solvent exchange method for growth factor delivery and determine the effectiveness of the composite scaffold containing the new growth factor delivery system in the cardiac tissue engineering model.


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